Non-cholinergic neurotoxic effects of AF64A in the substantia nigra

Aharon Levy, G. Jean Kant*, James L. Meyerhoff, Leonard E. Jarrard

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Ethylcholine aziridinium ion (AF64A), a putative specific cholinergic neurotoxin, was unilaterally injected into the substantia nigra of male rats. One week following injection, rats that were challenged with apomorphine exhibited ipsilateral circiling behavior. After two weeks, rats were sacrificed and corpus striatum and combined n.accumbens plus o. tubercle were assayed for dopamine. Striatal dopamine levels were depleted by 50%. Histological examination showed that AF64A caused extensive damage at the injection site. These data indicate that injection of AF64A into the substantia nigra can result in damage to dopaminergic neurons.

Original languageEnglish
Pages (from-to)169-172
Number of pages4
JournalBrain Research
Volume305
Issue number1
DOIs
StatePublished - 2 Jul 1984
Externally publishedYes

Keywords

  • AF64A
  • apomorphine circling behavior
  • cholinergic neurotoxin
  • dopamine depletion
  • ethylcholine aziridinium ion
  • nigro-striatal pathway
  • substantia nigra

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