Non-cholinergic neurotoxic effects of AF64A in the substantia nigra

Aharon Levy; G. Jean Kant; James L. Meyerhoff; Leonard E. Jarrard

doi:10.1016/0006-8993(84)91134-X

Non-cholinergic neurotoxic effects of AF64A in the substantia nigra

Aharon Levy, G. Jean Kant^*, James L. Meyerhoff, Leonard E. Jarrard

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Ethylcholine aziridinium ion (AF64A), a putative specific cholinergic neurotoxin, was unilaterally injected into the substantia nigra of male rats. One week following injection, rats that were challenged with apomorphine exhibited ipsilateral circiling behavior. After two weeks, rats were sacrificed and corpus striatum and combined n.accumbens plus o. tubercle were assayed for dopamine. Striatal dopamine levels were depleted by 50%. Histological examination showed that AF64A caused extensive damage at the injection site. These data indicate that injection of AF64A into the substantia nigra can result in damage to dopaminergic neurons.

Original language	English
Pages (from-to)	169-172
Number of pages	4
Journal	Brain Research
Volume	305
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(84)91134-X
State	Published - 2 Jul 1984
Externally published	Yes

Keywords

AF64A
apomorphine circling behavior
cholinergic neurotoxin
dopamine depletion
ethylcholine aziridinium ion
nigro-striatal pathway
substantia nigra

Access to Document

10.1016/0006-8993(84)91134-X

Cite this

@article{ea93138691f54719a57994d3672c36a9,

title = "Non-cholinergic neurotoxic effects of AF64A in the substantia nigra",

abstract = "Ethylcholine aziridinium ion (AF64A), a putative specific cholinergic neurotoxin, was unilaterally injected into the substantia nigra of male rats. One week following injection, rats that were challenged with apomorphine exhibited ipsilateral circiling behavior. After two weeks, rats were sacrificed and corpus striatum and combined n.accumbens plus o. tubercle were assayed for dopamine. Striatal dopamine levels were depleted by 50%. Histological examination showed that AF64A caused extensive damage at the injection site. These data indicate that injection of AF64A into the substantia nigra can result in damage to dopaminergic neurons.",

keywords = "AF64A, apomorphine circling behavior, cholinergic neurotoxin, dopamine depletion, ethylcholine aziridinium ion, nigro-striatal pathway, substantia nigra",

author = "Aharon Levy and Kant, {G. Jean} and Meyerhoff, {James L.} and Jarrard, {Leonard E.}",

year = "1984",

month = jul,

day = "2",

doi = "10.1016/0006-8993(84)91134-X",

language = "אנגלית",

volume = "305",

pages = "169--172",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Non-cholinergic neurotoxic effects of AF64A in the substantia nigra

AU - Levy, Aharon

AU - Kant, G. Jean

AU - Meyerhoff, James L.

AU - Jarrard, Leonard E.

PY - 1984/7/2

Y1 - 1984/7/2

N2 - Ethylcholine aziridinium ion (AF64A), a putative specific cholinergic neurotoxin, was unilaterally injected into the substantia nigra of male rats. One week following injection, rats that were challenged with apomorphine exhibited ipsilateral circiling behavior. After two weeks, rats were sacrificed and corpus striatum and combined n.accumbens plus o. tubercle were assayed for dopamine. Striatal dopamine levels were depleted by 50%. Histological examination showed that AF64A caused extensive damage at the injection site. These data indicate that injection of AF64A into the substantia nigra can result in damage to dopaminergic neurons.

AB - Ethylcholine aziridinium ion (AF64A), a putative specific cholinergic neurotoxin, was unilaterally injected into the substantia nigra of male rats. One week following injection, rats that were challenged with apomorphine exhibited ipsilateral circiling behavior. After two weeks, rats were sacrificed and corpus striatum and combined n.accumbens plus o. tubercle were assayed for dopamine. Striatal dopamine levels were depleted by 50%. Histological examination showed that AF64A caused extensive damage at the injection site. These data indicate that injection of AF64A into the substantia nigra can result in damage to dopaminergic neurons.

KW - AF64A

KW - apomorphine circling behavior

KW - cholinergic neurotoxin

KW - dopamine depletion

KW - ethylcholine aziridinium ion

KW - nigro-striatal pathway

KW - substantia nigra

UR - http://www.scopus.com/inward/record.url?scp=0021136197&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(84)91134-X

DO - 10.1016/0006-8993(84)91134-X

M3 - מאמר

C2 - 6547631

AN - SCOPUS:0021136197

VL - 305

SP - 169

EP - 172

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -

Non-cholinergic neurotoxic effects of AF64A in the substantia nigra

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this