Nocturnal growth hormone secretion in schizophrenic patients and healthy subjects

René S. Kahn, Michael Davidson, Jack Hirschowitz, Robert G. Stern, Bonnie M. David, Steve Gabriel, Clare Moore, Kenneth L. Davis

Research output: Contribution to journalArticlepeer-review


Plasma growth hormone concentrations were measured at hourly intervals between 10 p.m. and 8 a.m. the next morning in 15 drug-free chronic schizophrenic male inpatients and 14 healthy males. Growth hormone secretion was significantly lower in the patients as compared with the controls. Growth hormone release peaked around 1 a.m. in the controls, but a growth hormone peak was absent in the patient group. Increased dopamine activity, increased serotonin activity, or both could explain the absence of a nocturnal growth hormone surge in the schizophrenic patients.

Original languageEnglish
Pages (from-to)155-161
Number of pages7
JournalPsychiatry Research
Issue number2
StatePublished - Feb 1992
Externally publishedYes


  • Psychoendocrinology
  • dopamine
  • hormones
  • serotonin


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