Nociceptive circling and naloxone

R. Rabinowitz, N. Shlesinger, A. D. Korczyn*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Under suitable conditions, mice exhibit rotatory behaviour, with a direction preference. Noxious electric stimulation to the feet of mice was found to increase significantly the rate of turning, as well as the ratio between circling in the preferred and in the opposite direction (the latter change was not significant statistically). Naloxone injected prior to the stimulation period tended to reverse the effects of the stimulation. These facts may imply that enkephalins are released during this stimulation and influence rotatory behaviour.

Original languageEnglish
Pages (from-to)963-967
Number of pages5
JournalPharmacological Research Communications
Issue number10
StatePublished - Nov 1983


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