No Linkage between HLA and Congenital Adrenal Hyperplasia Due to 11-β-Hydroxylase Deficiency

C. Brautbar; A. Rösler; H. Landau; I. Cohen; D. Nelken; T. Cohen; C. Levine; J. Sack; A. Benderli; S. Moses; E. Lieberman; B. Dupont; L. S. Levine; M. I. New

doi:10.1056/NEJM197901253000433

No Linkage between HLA and Congenital Adrenal Hyperplasia Due to 11-β-Hydroxylase Deficiency

C. Brautbar, A. Rösler, H. Landau, I. Cohen, D. Nelken, T. Cohen, C. Levine, J. Sack, A. Benderli, S. Moses, E. Lieberman, B. Dupont, L. S. Levine, M. I. New

Research output: Contribution to journal › Letter › peer-review

Abstract

To the Editor: The various forms of congenital adrenal hyperplasia are caused by different enzymatic deficiencies, each responsible for a given step in the biosynthesis of cortisol or aldosterone (or both). The most frequent forms of this disorder result from deficiencies of the 21-hydroxylase and 11-hydroxylase enzymes.¹ These enzymes function sequentially in steroid biosynthesis and therefore may be genetically linked, similar perhaps to the lactose system in Escherichia coli.² Since close genetic linkage between congenital adrenal hyperplasia, 21-hydroxylase deficiency and the B locus of the HLA system has recently been shown,³ ⁴ ⁵ it was of interest to determine if the.

Original language	English
Pages (from-to)	205-206
Number of pages	2
Journal	New England Journal of Medicine
Volume	300
Issue number	4
DOIs	https://doi.org/10.1056/NEJM197901253000433
State	Published - 25 Jan 1979
Externally published	Yes

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Brautbar, C., Rösler, A., Landau, H., Cohen, I., Nelken, D., Cohen, T., Levine, C., Sack, J., Benderli, A., Moses, S., Lieberman, E., Dupont, B., Levine, L. S., & New, M. I. (1979). No Linkage between HLA and Congenital Adrenal Hyperplasia Due to 11-β-Hydroxylase Deficiency. New England Journal of Medicine, 300(4), 205-206. https://doi.org/10.1056/NEJM197901253000433

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abstract = "To the Editor: The various forms of congenital adrenal hyperplasia are caused by different enzymatic deficiencies, each responsible for a given step in the biosynthesis of cortisol or aldosterone (or both). The most frequent forms of this disorder result from deficiencies of the 21-hydroxylase and 11-hydroxylase enzymes.1 These enzymes function sequentially in steroid biosynthesis and therefore may be genetically linked, similar perhaps to the lactose system in Escherichia coli.2 Since close genetic linkage between congenital adrenal hyperplasia, 21-hydroxylase deficiency and the B locus of the HLA system has recently been shown,3 4 5 it was of interest to determine if the.",

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AU - Cohen, I.

AU - Nelken, D.

AU - Cohen, T.

AU - Levine, C.

AU - Sack, J.

AU - Benderli, A.

AU - Moses, S.

AU - Lieberman, E.

AU - Dupont, B.

AU - Levine, L. S.

AU - New, M. I.

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AB - To the Editor: The various forms of congenital adrenal hyperplasia are caused by different enzymatic deficiencies, each responsible for a given step in the biosynthesis of cortisol or aldosterone (or both). The most frequent forms of this disorder result from deficiencies of the 21-hydroxylase and 11-hydroxylase enzymes.1 These enzymes function sequentially in steroid biosynthesis and therefore may be genetically linked, similar perhaps to the lactose system in Escherichia coli.2 Since close genetic linkage between congenital adrenal hyperplasia, 21-hydroxylase deficiency and the B locus of the HLA system has recently been shown,3 4 5 it was of interest to determine if the.

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No Linkage between HLA and Congenital Adrenal Hyperplasia Due to 11-β-Hydroxylase Deficiency

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