No correlation between diffuse idiopathic skeletal hyperostosis and coronary artery disease on computed tomography using two different scoring systems

Christine Dan Lantsman, Yafim Brodov, Shlomi Matetzky, Roi Beigel, Merav Lidar, Iris Eshed*, Orly Goitein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: An association between diffuse idiopathic skeletal hyperostosis (DISH) and a history of coronary artery disease (CAD) was previously reported. Purpose: To investigate the association between DISH and CAD as assessed using the coronary artery calcification score (CACS) and the CAD-Reporting and Data System (CAD-RADS) score in patients with symptomatic chest pain. Material and Methods: Consecutive cardiac CT scans performed before and after IV contrast administration were evaluated for CACS (Agatston method), CAD-RADS, and the presence of DISH. The association of DISH with the presence and extent of CACS/CAD-RADS scores was analyzed with and without adjustment for known atherosclerotic risk factors. Results: The study cohort included 268 individuals (157 men, 111 women; median age = 54 years). DISH was present in 65 (24.3%) individuals. CACS was significantly higher in the DISH group compared to the non-DISH group in the univariate analysis (median CACS DISH = 2, range = 0–80.5 vs. median CACS non-DISH = 0, range = 0–11; P < 0.005) but this association did not persist on multivariate analysis. There was a positive trend toward higher CAD-RADS scores in the DISH group (P = 0.03) but after adjustment for age, male sex, and family history, this tendency was not significant. Conclusion: No independent association was found between the presence of DISH and CACS and CAD-RADS scores. Our findings suggest a more complex and possibly non-causal relationship between coronary artery disease and DISH.

Original languageEnglish
Pages (from-to)508-514
Number of pages7
JournalActa Radiologica
Volume64
Issue number2
DOIs
StatePublished - Feb 2023

Keywords

  • Diffuse idiopathic skeletal hyperostosis
  • calcification
  • computed tomography
  • coronaries

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