NMR Spectroscopy of Bilirubin and its Derivatives

Doron Kaplan*, Gil Navon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Literature NMR data of bilirubin and related compounds and their interpretation in terms of structure, solution conformation and dynamic properties have been reviewed. 1H‐spectrum assignments as well as solvent and temperature dependencies of the chemical shifts are described. Proton exchange rates, longitudinal relaxation times and nuclear Overhauser enhancements are surveyed. NMR is shown to provide knowledge on the basic structure, conformation, tautomerism, hydrogen bonding, acidity constants, segmental motion of side‐chains, interconversion between enantiomers and aggregation—disaggregation of these compounds in solution.

Original languageEnglish
Pages (from-to)177-186
Number of pages10
JournalIsrael Journal of Chemistry
Issue number2
StatePublished - 1983


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