Njaoamines G and H, two new cytotoxic polycyclic alkaloids and a tetrahydroquinolone from the marine sponge Neopetrosia sp.

Hagit Sorek; Amira Rudi; Yehuda Benayahu; Yoel Kashman

doi:10.1016/j.tetlet.2007.08.079

Njaoamines G and H, two new cytotoxic polycyclic alkaloids and a tetrahydroquinolone from the marine sponge Neopetrosia sp.

Hagit Sorek, Amira Rudi, Yehuda Benayahu, Yoel Kashman^*

^*Corresponding author for this work

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Two new polycyclic alkaloids, njaoamines G (1) and H (2) and 1,2,3,4-tetrahydroquinolin-4-one (3) have been isolated from the sponge Neopetrosia sp. collected at Pemba Island, Tanzania. Compounds 1 and 2 are close in structure to njaoamines A-F. Compound 3, known synthetically, is a new natural compound. The structures and relative stereochemistries of compounds 1 and 2 were elucidated on the basis of spectroscopic data. Njaoamines G and H are potent brine shrimp toxins with LD₅₀ values of 0.17 μg/mL and 0.08 μg/mL for 1 and 2, respectively.

Original language	English
Pages (from-to)	7691-7694
Number of pages	4
Journal	Tetrahedron Letters
Volume	48
Issue number	43
DOIs	https://doi.org/10.1016/j.tetlet.2007.08.079
State	Published - 22 Oct 2007

Keywords

Alkaloids
Marine sponge
NMR
Quinoline

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title = "Njaoamines G and H, two new cytotoxic polycyclic alkaloids and a tetrahydroquinolone from the marine sponge Neopetrosia sp.",

abstract = "Two new polycyclic alkaloids, njaoamines G (1) and H (2) and 1,2,3,4-tetrahydroquinolin-4-one (3) have been isolated from the sponge Neopetrosia sp. collected at Pemba Island, Tanzania. Compounds 1 and 2 are close in structure to njaoamines A-F. Compound 3, known synthetically, is a new natural compound. The structures and relative stereochemistries of compounds 1 and 2 were elucidated on the basis of spectroscopic data. Njaoamines G and H are potent brine shrimp toxins with LD50 values of 0.17 μg/mL and 0.08 μg/mL for 1 and 2, respectively.",

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T1 - Njaoamines G and H, two new cytotoxic polycyclic alkaloids and a tetrahydroquinolone from the marine sponge Neopetrosia sp.

AU - Sorek, Hagit

AU - Rudi, Amira

AU - Benayahu, Yehuda

AU - Kashman, Yoel

PY - 2007/10/22

Y1 - 2007/10/22

N2 - Two new polycyclic alkaloids, njaoamines G (1) and H (2) and 1,2,3,4-tetrahydroquinolin-4-one (3) have been isolated from the sponge Neopetrosia sp. collected at Pemba Island, Tanzania. Compounds 1 and 2 are close in structure to njaoamines A-F. Compound 3, known synthetically, is a new natural compound. The structures and relative stereochemistries of compounds 1 and 2 were elucidated on the basis of spectroscopic data. Njaoamines G and H are potent brine shrimp toxins with LD50 values of 0.17 μg/mL and 0.08 μg/mL for 1 and 2, respectively.

AB - Two new polycyclic alkaloids, njaoamines G (1) and H (2) and 1,2,3,4-tetrahydroquinolin-4-one (3) have been isolated from the sponge Neopetrosia sp. collected at Pemba Island, Tanzania. Compounds 1 and 2 are close in structure to njaoamines A-F. Compound 3, known synthetically, is a new natural compound. The structures and relative stereochemistries of compounds 1 and 2 were elucidated on the basis of spectroscopic data. Njaoamines G and H are potent brine shrimp toxins with LD50 values of 0.17 μg/mL and 0.08 μg/mL for 1 and 2, respectively.

KW - Alkaloids

KW - Marine sponge

KW - NMR

KW - Quinoline

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SN - 0040-4039

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

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Njaoamines G and H, two new cytotoxic polycyclic alkaloids and a tetrahydroquinolone from the marine sponge Neopetrosia sp.

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