Njaoamines G and H, two new cytotoxic polycyclic alkaloids and a tetrahydroquinolone from the marine sponge Neopetrosia sp.

Hagit Sorek, Amira Rudi, Yehuda Benayahu, Yoel Kashman

Research output: Contribution to journalArticlepeer-review

Abstract

Two new polycyclic alkaloids, njaoamines G (1) and H (2) and 1,2,3,4-tetrahydroquinolin-4-one (3) have been isolated from the sponge Neopetrosia sp. collected at Pemba Island, Tanzania. Compounds 1 and 2 are close in structure to njaoamines A-F. Compound 3, known synthetically, is a new natural compound. The structures and relative stereochemistries of compounds 1 and 2 were elucidated on the basis of spectroscopic data. Njaoamines G and H are potent brine shrimp toxins with LD50 values of 0.17 μg/mL and 0.08 μg/mL for 1 and 2, respectively.

Original languageEnglish
Pages (from-to)7691-7694
Number of pages4
JournalTetrahedron Letters
Volume48
Issue number43
DOIs
StatePublished - 22 Oct 2007

Keywords

  • Alkaloids
  • Marine sponge
  • NMR
  • Quinoline

Fingerprint

Dive into the research topics of 'Njaoamines G and H, two new cytotoxic polycyclic alkaloids and a tetrahydroquinolone from the marine sponge Neopetrosia sp.'. Together they form a unique fingerprint.

Cite this