Nilotinib 300mg BID as frontline treatment of CML: Prospective analysis of the Xpert BCR-ABL Monitor system and significance of 3-month molecular response

Michael E. O'Dwyer; Ronan Swords; Arnon Nagler; Mary Frances McMullin; Philipp D. le Coutre; Stephen E. Langabeer; Alberto Alvarez-Iglesias; Hongxin Fan; Richard C. Woodman; Francis J. Giles; Eibhlin Conneally

doi:10.1016/j.leukres.2013.11.016

Nilotinib 300mg BID as frontline treatment of CML: Prospective analysis of the Xpert BCR-ABL Monitor system and significance of 3-month molecular response

Michael E. O'Dwyer^*, Ronan Swords, Arnon Nagler, Mary Frances McMullin, Philipp D. le Coutre, Stephen E. Langabeer, Alberto Alvarez-Iglesias, Hongxin Fan, Richard C. Woodman, Francis J. Giles, Eibhlin Conneally

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Sixty patients with early chronic phase CML (ECPCML) received Nilotinib on a phase II study which included a comparison of the Xpert BCR-ABL Monitor™ PCR system with standardized (IS) BCR-ABL1 real-time quantitative PCR (RQ-PCR). 88% patients achieved MMR with 45% achieving MR4.5. At 3 months BCR-ABL1/ABL1 IS >1% and <10% was associated with a lower likelihood of subsequent MR4.5 compared to patients with lower levels (p= 0.018). No significant difference was observed between methodologies in identifying MMR. Nilotinib induces high molecular response rates in ECPCML and the Xpert BCR-ABL Monitor™ system merits further investigation in this setting.

Original language	English
Pages (from-to)	310-315
Number of pages	6
Journal	Leukemia Research
Volume	38
Issue number	3
DOIs	https://doi.org/10.1016/j.leukres.2013.11.016
State	Published - Mar 2014
Externally published	Yes

Keywords

CML BCR-ABL
Minimal residual disease
Molecular diagnostics
Nilotinib

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.leukres.2013.11.016

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O'Dwyer, M. E., Swords, R., Nagler, A., McMullin, M. F., le Coutre, P. D., Langabeer, S. E., Alvarez-Iglesias, A., Fan, H., Woodman, R. C., Giles, F. J., & Conneally, E. (2014). Nilotinib 300mg BID as frontline treatment of CML: Prospective analysis of the Xpert BCR-ABL Monitor system and significance of 3-month molecular response. Leukemia Research, 38(3), 310-315. https://doi.org/10.1016/j.leukres.2013.11.016

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title = "Nilotinib 300mg BID as frontline treatment of CML: Prospective analysis of the Xpert BCR-ABL Monitor system and significance of 3-month molecular response",

abstract = "Sixty patients with early chronic phase CML (ECPCML) received Nilotinib on a phase II study which included a comparison of the Xpert BCR-ABL Monitor{\texttrademark} PCR system with standardized (IS) BCR-ABL1 real-time quantitative PCR (RQ-PCR). 88% patients achieved MMR with 45% achieving MR4.5. At 3 months BCR-ABL1/ABL1 IS >1% and <10% was associated with a lower likelihood of subsequent MR4.5 compared to patients with lower levels (p= 0.018). No significant difference was observed between methodologies in identifying MMR. Nilotinib induces high molecular response rates in ECPCML and the Xpert BCR-ABL Monitor{\texttrademark} system merits further investigation in this setting.",

keywords = "CML BCR-ABL, Minimal residual disease, Molecular diagnostics, Nilotinib",

author = "O'Dwyer, {Michael E.} and Ronan Swords and Arnon Nagler and McMullin, {Mary Frances} and {le Coutre}, {Philipp D.} and Langabeer, {Stephen E.} and Alberto Alvarez-Iglesias and Hongxin Fan and Woodman, {Richard C.} and Giles, {Francis J.} and Eibhlin Conneally",

note = "Funding Information: MEOD, RS, AN, FJG, PDLC, MFMM and EC have consulted for, and received research funding from, Novartis. RCW is a Novartis employee and stockholder. ",

year = "2014",

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doi = "10.1016/j.leukres.2013.11.016",

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volume = "38",

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O'Dwyer, ME, Swords, R, Nagler, A, McMullin, MF, le Coutre, PD, Langabeer, SE, Alvarez-Iglesias, A, Fan, H, Woodman, RC, Giles, FJ & Conneally, E 2014, 'Nilotinib 300mg BID as frontline treatment of CML: Prospective analysis of the Xpert BCR-ABL Monitor system and significance of 3-month molecular response', Leukemia Research, vol. 38, no. 3, pp. 310-315. https://doi.org/10.1016/j.leukres.2013.11.016

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AU - Nagler, Arnon

AU - McMullin, Mary Frances

AU - le Coutre, Philipp D.

AU - Langabeer, Stephen E.

AU - Alvarez-Iglesias, Alberto

AU - Fan, Hongxin

AU - Woodman, Richard C.

AU - Giles, Francis J.

AU - Conneally, Eibhlin

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AB - Sixty patients with early chronic phase CML (ECPCML) received Nilotinib on a phase II study which included a comparison of the Xpert BCR-ABL Monitor™ PCR system with standardized (IS) BCR-ABL1 real-time quantitative PCR (RQ-PCR). 88% patients achieved MMR with 45% achieving MR4.5. At 3 months BCR-ABL1/ABL1 IS >1% and <10% was associated with a lower likelihood of subsequent MR4.5 compared to patients with lower levels (p= 0.018). No significant difference was observed between methodologies in identifying MMR. Nilotinib induces high molecular response rates in ECPCML and the Xpert BCR-ABL Monitor™ system merits further investigation in this setting.

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Nilotinib 300mg BID as frontline treatment of CML: Prospective analysis of the Xpert BCR-ABL Monitor system and significance of 3-month molecular response

Abstract

Keywords

UN SDGs

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