Nifedipine GITS Replacing Nifedipine SR: Ambulatory Blood Pressure Assessment of Efficacy

Cannit Rahima-Maoz, Ehud Grossman, Naomi Nussinovitch, Arieh Katz, Talma Rosenthal

Research output: Contribution to journalArticlepeer-review

Abstract

The relative efficacy of two formulations of nifedipine, slow release (SR) and gastrointestinal therapeutic system (GITS), to lower blood pressure in hypertensive patients was evaluated in a prospective study. Nifedipine GITS 30 mg/day replaced nifedipine SR, 20 mg b.i.d. in 38 patients, 23 monitored by routine blood pressure measurements and 15 by ambulatory monitoring. Nifedipine GITS achieved a marked reduction in blood pressure with a smaller dose than nifedipine SR: 30 versus 40 mg/day, respectively. It is concluded that patients with hypertension controlled on a twice-daily dose of nifedipine prolonged action can be converted to a lower once-daily dose of nifedipine GITS without experiencing any increase in blood pressure. Tolerability and compliance improved when switching to the GITS formulation.

Original languageEnglish
Pages (from-to)43-46
Number of pages4
JournalCardiology
Volume88
DOIs
StatePublished - 1 Jan 1997

Keywords

  • Ambulatory blood pressure Monitoring
  • Hypertension
  • Nifedipine GITS
  • Nifedipine SR

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