Nifedipine GITS Replacing Nifedipine SR: Ambulatory Blood Pressure Assessment of Efficacy

Cannit Rahima-Maoz; Ehud Grossman; Naomi Nussinovitch; Arieh Katz; Talma Rosenthal

doi:10.1159/000177506

Nifedipine GITS Replacing Nifedipine SR: Ambulatory Blood Pressure Assessment of Efficacy

Cannit Rahima-Maoz, Ehud Grossman, Naomi Nussinovitch, Arieh Katz, Talma Rosenthal

Faculty of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The relative efficacy of two formulations of nifedipine, slow release (SR) and gastrointestinal therapeutic system (GITS), to lower blood pressure in hypertensive patients was evaluated in a prospective study. Nifedipine GITS 30 mg/day replaced nifedipine SR, 20 mg b.i.d. in 38 patients, 23 monitored by routine blood pressure measurements and 15 by ambulatory monitoring. Nifedipine GITS achieved a marked reduction in blood pressure with a smaller dose than nifedipine SR: 30 versus 40 mg/day, respectively. It is concluded that patients with hypertension controlled on a twice-daily dose of nifedipine prolonged action can be converted to a lower once-daily dose of nifedipine GITS without experiencing any increase in blood pressure. Tolerability and compliance improved when switching to the GITS formulation.

Original language	English
Pages (from-to)	43-46
Number of pages	4
Journal	Cardiology
Volume	88
DOIs	https://doi.org/10.1159/000177506
State	Published - 1 Jan 1997

Keywords

Ambulatory blood pressure Monitoring
Hypertension
Nifedipine GITS
Nifedipine SR

Access to Document

10.1159/000177506

Cite this

@article{c1835a022e1548589f629e8839e3380e,

title = "Nifedipine GITS Replacing Nifedipine SR: Ambulatory Blood Pressure Assessment of Efficacy",

abstract = "The relative efficacy of two formulations of nifedipine, slow release (SR) and gastrointestinal therapeutic system (GITS), to lower blood pressure in hypertensive patients was evaluated in a prospective study. Nifedipine GITS 30 mg/day replaced nifedipine SR, 20 mg b.i.d. in 38 patients, 23 monitored by routine blood pressure measurements and 15 by ambulatory monitoring. Nifedipine GITS achieved a marked reduction in blood pressure with a smaller dose than nifedipine SR: 30 versus 40 mg/day, respectively. It is concluded that patients with hypertension controlled on a twice-daily dose of nifedipine prolonged action can be converted to a lower once-daily dose of nifedipine GITS without experiencing any increase in blood pressure. Tolerability and compliance improved when switching to the GITS formulation.",

keywords = "Ambulatory blood pressure Monitoring, Hypertension, Nifedipine GITS, Nifedipine SR",

author = "Cannit Rahima-Maoz and Ehud Grossman and Naomi Nussinovitch and Arieh Katz and Talma Rosenthal",

year = "1997",

month = jan,

day = "1",

doi = "10.1159/000177506",

language = "אנגלית",

volume = "88",

pages = "43--46",

journal = "Cardiology",

issn = "0008-6312",

publisher = "S. Karger AG",

}

TY - JOUR

T1 - Nifedipine GITS Replacing Nifedipine SR

T2 - Ambulatory Blood Pressure Assessment of Efficacy

AU - Rahima-Maoz, Cannit

AU - Grossman, Ehud

AU - Nussinovitch, Naomi

AU - Katz, Arieh

AU - Rosenthal, Talma

PY - 1997/1/1

Y1 - 1997/1/1

N2 - The relative efficacy of two formulations of nifedipine, slow release (SR) and gastrointestinal therapeutic system (GITS), to lower blood pressure in hypertensive patients was evaluated in a prospective study. Nifedipine GITS 30 mg/day replaced nifedipine SR, 20 mg b.i.d. in 38 patients, 23 monitored by routine blood pressure measurements and 15 by ambulatory monitoring. Nifedipine GITS achieved a marked reduction in blood pressure with a smaller dose than nifedipine SR: 30 versus 40 mg/day, respectively. It is concluded that patients with hypertension controlled on a twice-daily dose of nifedipine prolonged action can be converted to a lower once-daily dose of nifedipine GITS without experiencing any increase in blood pressure. Tolerability and compliance improved when switching to the GITS formulation.

AB - The relative efficacy of two formulations of nifedipine, slow release (SR) and gastrointestinal therapeutic system (GITS), to lower blood pressure in hypertensive patients was evaluated in a prospective study. Nifedipine GITS 30 mg/day replaced nifedipine SR, 20 mg b.i.d. in 38 patients, 23 monitored by routine blood pressure measurements and 15 by ambulatory monitoring. Nifedipine GITS achieved a marked reduction in blood pressure with a smaller dose than nifedipine SR: 30 versus 40 mg/day, respectively. It is concluded that patients with hypertension controlled on a twice-daily dose of nifedipine prolonged action can be converted to a lower once-daily dose of nifedipine GITS without experiencing any increase in blood pressure. Tolerability and compliance improved when switching to the GITS formulation.

KW - Ambulatory blood pressure Monitoring

KW - Hypertension

KW - Nifedipine GITS

KW - Nifedipine SR

UR - http://www.scopus.com/inward/record.url?scp=0030735507&partnerID=8YFLogxK

U2 - 10.1159/000177506

DO - 10.1159/000177506

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

AN - SCOPUS:0030735507

VL - 88

SP - 43

EP - 46

JO - Cardiology

JF - Cardiology

SN - 0008-6312

ER -

Nifedipine GITS Replacing Nifedipine SR: Ambulatory Blood Pressure Assessment of Efficacy

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this