Nicotinic acetylcholine receptor α5 subunits modulate oxotremorine-induced salivation and tremor

Ningshan Wang; Avi Orr-Urtreger; Joab Chapman; Ruth Rabinowitz; Amos D. Korczyn

doi:10.1016/j.jns.2004.04.009

Nicotinic acetylcholine receptor α5 subunits modulate oxotremorine-induced salivation and tremor

Ningshan Wang, Avi Orr-Urtreger, Joab Chapman, Ruth Rabinowitz, Amos D. Korczyn^*

^*Corresponding author for this work

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Neuronal nicotinic acetylcholine receptors (nAChRs) are composed of 12 subunits (α2-α10 and β2-β4). α5 Subunits, expressed throughout the central nervous system (CNS) and the autonomic nervous system (ANS), possess unique pharmacological properties. The effects of oxotremorine (OXO) on autonomic functions and tremor were examined in mice lacking α5 nAChR subunits (α5-/-) and compared with those in wild-type (WT) control mice. The α5-/- mice showed significantly increased salivation and tremor responses to OXO. The hypothermia, bradycardia and defecation induced by OXO were of similar magnitudes in the two mouse strains. The enhanced OXO effects in α5-/- mice indicate inhibitory effects of α5 subunits in autonomic ganglia, and support the participation of these subunits in cholinergic transmission in autonomic ganglia.

Original language	English
Pages (from-to)	87-91
Number of pages	5
Journal	Journal of the Neurological Sciences
Volume	222
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jns.2004.04.009
State	Published - 15 Jul 2004

Funding

Funders	Funder number
Miriam Turjanski de Gold foundation
Tel Aviv University

Keywords

Alpha5 subunit
Autonomic nervous system
Heart rate
Knockout mice
Nicotinic receptors
Oxotremorine
Salivation
Tremor

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10.1016/j.jns.2004.04.009

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@article{9020288dadbf405fae42e661f16a1704,

title = "Nicotinic acetylcholine receptor α5 subunits modulate oxotremorine-induced salivation and tremor",

abstract = "Neuronal nicotinic acetylcholine receptors (nAChRs) are composed of 12 subunits (α2-α10 and β2-β4). α5 Subunits, expressed throughout the central nervous system (CNS) and the autonomic nervous system (ANS), possess unique pharmacological properties. The effects of oxotremorine (OXO) on autonomic functions and tremor were examined in mice lacking α5 nAChR subunits (α5-/-) and compared with those in wild-type (WT) control mice. The α5-/- mice showed significantly increased salivation and tremor responses to OXO. The hypothermia, bradycardia and defecation induced by OXO were of similar magnitudes in the two mouse strains. The enhanced OXO effects in α5-/- mice indicate inhibitory effects of α5 subunits in autonomic ganglia, and support the participation of these subunits in cholinergic transmission in autonomic ganglia.",

keywords = "Alpha5 subunit, Autonomic nervous system, Heart rate, Knockout mice, Nicotinic receptors, Oxotremorine, Salivation, Tremor",

author = "Ningshan Wang and Avi Orr-Urtreger and Joab Chapman and Ruth Rabinowitz and Korczyn, {Amos D.}",

note = "Funding Information: This work was supported by the Sieratzki Chair of Neurology, Tel Aviv University, and the Miriam Turjanski de Gold foundation and by M.K. Humanitarian Fund to A. Orr-Urtreger.",

year = "2004",

month = jul,

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doi = "10.1016/j.jns.2004.04.009",

language = "אנגלית",

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AU - Wang, Ningshan

AU - Orr-Urtreger, Avi

AU - Chapman, Joab

AU - Rabinowitz, Ruth

AU - Korczyn, Amos D.

N1 - Funding Information: This work was supported by the Sieratzki Chair of Neurology, Tel Aviv University, and the Miriam Turjanski de Gold foundation and by M.K. Humanitarian Fund to A. Orr-Urtreger.

PY - 2004/7/15

Y1 - 2004/7/15

N2 - Neuronal nicotinic acetylcholine receptors (nAChRs) are composed of 12 subunits (α2-α10 and β2-β4). α5 Subunits, expressed throughout the central nervous system (CNS) and the autonomic nervous system (ANS), possess unique pharmacological properties. The effects of oxotremorine (OXO) on autonomic functions and tremor were examined in mice lacking α5 nAChR subunits (α5-/-) and compared with those in wild-type (WT) control mice. The α5-/- mice showed significantly increased salivation and tremor responses to OXO. The hypothermia, bradycardia and defecation induced by OXO were of similar magnitudes in the two mouse strains. The enhanced OXO effects in α5-/- mice indicate inhibitory effects of α5 subunits in autonomic ganglia, and support the participation of these subunits in cholinergic transmission in autonomic ganglia.

AB - Neuronal nicotinic acetylcholine receptors (nAChRs) are composed of 12 subunits (α2-α10 and β2-β4). α5 Subunits, expressed throughout the central nervous system (CNS) and the autonomic nervous system (ANS), possess unique pharmacological properties. The effects of oxotremorine (OXO) on autonomic functions and tremor were examined in mice lacking α5 nAChR subunits (α5-/-) and compared with those in wild-type (WT) control mice. The α5-/- mice showed significantly increased salivation and tremor responses to OXO. The hypothermia, bradycardia and defecation induced by OXO were of similar magnitudes in the two mouse strains. The enhanced OXO effects in α5-/- mice indicate inhibitory effects of α5 subunits in autonomic ganglia, and support the participation of these subunits in cholinergic transmission in autonomic ganglia.

KW - Alpha5 subunit

KW - Autonomic nervous system

KW - Heart rate

KW - Knockout mice

KW - Nicotinic receptors

KW - Oxotremorine

KW - Salivation

KW - Tremor

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SN - 0022-510X

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ER -

Nicotinic acetylcholine receptor α5 subunits modulate oxotremorine-induced salivation and tremor

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