Nickel-Catalyzed Phosphine Free Direct N-Alkylation of Amides with Alcohols

Jagadish Das, Debasis Banerjee*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Herein, we developed an operational simple, practical, and selective Ni-catalyzed synthesis of secondary amides. Application of renewable alcohols, earth-abundant and nonprecious nickel catalyst facilitates the transformations, releasing water as byproduct. The catalytic system is tolerant to a variety of functional groups including nitrile, allylic ether, and alkene and could be extended to the synthesis of bis-amide, antiemetic drug Tigan, and dopamine D2 receptor antagonist Itopride. Preliminary mechanistic studies revealed the participation of a benzylic C-H bond in the rate-determining step.

Original languageEnglish
Pages (from-to)3378-3384
Number of pages7
JournalJournal of Organic Chemistry
Issue number6
StatePublished - 16 Mar 2018
Externally publishedYes


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