Nickel-catalysed alkylation of C(sp3)-H bonds with alcohols: direct access to functionalised N-heteroaromatics

Mari Vellakkaran; Jagadish Das; Sourajit Bera; Debasis Banerjee

doi:10.1039/c8cc06370b

Nickel-catalysed alkylation of C(sp³)-H bonds with alcohols: direct access to functionalised N-heteroaromatics

Mari Vellakkaran, Jagadish Das, Sourajit Bera, Debasis Banerjee^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The first base-metal catalysed coupling of primary alcohols with methyl-N-heteroaromatics is reported. The use of an earth abundant and nonprecious NiBr₂/L1 system enables access to a series of C(sp³)-alkylated N-heteroaromatics. Mechanistic studies have established the participation of a hydrogen-borrowing strategy for α-alkylation.

Original language	English
Pages (from-to)	12369-12372
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	87
DOIs	https://doi.org/10.1039/c8cc06370b
State	Published - 2018
Externally published	Yes

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abstract = "The first base-metal catalysed coupling of primary alcohols with methyl-N-heteroaromatics is reported. The use of an earth abundant and nonprecious NiBr2/L1 system enables access to a series of C(sp3)-alkylated N-heteroaromatics. Mechanistic studies have established the participation of a hydrogen-borrowing strategy for α-alkylation.",

author = "Mari Vellakkaran and Jagadish Das and Sourajit Bera and Debasis Banerjee",

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AU - Bera, Sourajit

AU - Banerjee, Debasis

N1 - Publisher Copyright: © The Royal Society of Chemistry.

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Y1 - 2018

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AB - The first base-metal catalysed coupling of primary alcohols with methyl-N-heteroaromatics is reported. The use of an earth abundant and nonprecious NiBr2/L1 system enables access to a series of C(sp3)-alkylated N-heteroaromatics. Mechanistic studies have established the participation of a hydrogen-borrowing strategy for α-alkylation.

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IS - 87

ER -

Nickel-catalysed alkylation of C(sp³)-H bonds with alcohols: direct access to functionalised N-heteroaromatics

Abstract

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