New trends in the diagnosis and treatment of renal cell carcinoma

Amnon Zisman*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


In the last decade the treatment of renal cell carcinoma (RCC) have changed dramatically. Currently, laparoscopic radical nephrectomy, partial nephrectomy in the presence of normal contralateral kidney as well as ablative surgery for small renal masses, are vivid options for the treatment of localized RCC. For metastatic RCC, cytoreductive nephrectomy is the standard of care prior to immunotherapy or combined treatment with tumor vaccines. On the horizon are: laparoscopic partial nephrectomy for localized disease and allogenic dendritic cell--autologous tumor cell hybrid vaccines as a non-toxic tumor vaccine. More experimental therapies involving targeting RCC cells using specific markers such as G250 are under investigation. In addition, changes in the 1997 TNM classification of RCC are anticipated. Retiring--routine adrenalectomy during radical nephrectomy and immunotherapy using tumor infiltrating lymphocytes (TIL).

Original languageEnglish
Pages (from-to)713-717, 761
Issue number8
StatePublished - Aug 2002
Externally publishedYes


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