TY - JOUR
T1 - New strategies in breast cancer
T2 - The significance of molecular subtypes in systemic adjuvant treatment for small T1a,bN0M0 tumors
AU - Sonnenblick, Amir
AU - Fumagalli, Debora
AU - Azim, Hatem A.
AU - Sotiriou, Christos
AU - Piccart, Martine
N1 - Publisher Copyright:
©2014 American Association for Cancer Research.
PY - 2014/12/15
Y1 - 2014/12/15
N2 - Awareness of breast cancer heterogeneity has strikingly increased in the past decade in parallel with the development of high-throughput molecular tests. Beyond the clear usefulness of antiestrogen treatment in luminal tumors and trastuzumab in HER2-positive tumors, breast cancer subtypes may have additional clinical and predictive roles that can be relevant to clinical practice. In this article, we discuss the significance of molecular subtypes in the systemic treatment of early-stage breast tumors smaller than 1 cm ( T1a,bN0 M0) and suggest new strategies for future treatment recommendations for these patients.
AB - Awareness of breast cancer heterogeneity has strikingly increased in the past decade in parallel with the development of high-throughput molecular tests. Beyond the clear usefulness of antiestrogen treatment in luminal tumors and trastuzumab in HER2-positive tumors, breast cancer subtypes may have additional clinical and predictive roles that can be relevant to clinical practice. In this article, we discuss the significance of molecular subtypes in the systemic treatment of early-stage breast tumors smaller than 1 cm ( T1a,bN0 M0) and suggest new strategies for future treatment recommendations for these patients.
UR - http://www.scopus.com/inward/record.url?scp=84919619363&partnerID=8YFLogxK
U2 - 10.1158/1078-0432.CCR-14-1086
DO - 10.1158/1078-0432.CCR-14-1086
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C2 - 25336696
AN - SCOPUS:84919619363
SN - 1078-0432
VL - 20
SP - 6242
EP - 6246
JO - Clinical Cancer Research
JF - Clinical Cancer Research
IS - 24
ER -
