New sesterterpenes from Madagascan Lendenfeldia sponges

Liat Chill, Amira Rudi, Maurice Aknin, Shoshana Loya, Amnon Hizi, Yoel Kashman

Research output: Contribution to journalArticlepeer-review


A new furanoterpene designated dehydrofurodendin and nine scalarane sesterterpenes of which four are new, were isolated from two different species of Madagascan sponges of the genus Lendenfeldia, both of which seem to be yet undescribed. The structure of the compounds was elucidated by interpretation of 1D and 2D NMR data. Dehydrofurodendin was found to be a potent inhibitor of HIV-1 RT. Several of the isolated scalaranes exhibited cyctotoxicity against several human tumor cells. A new furanoterpene (1), and nine scalarane sesterterpenes, of which four (2, 6-8) are new, were isolated from Madagascan Lendenfeldia sponges. Compound 1 was found to be a potent inhibitor of HIV-1 RT. Compounds 2, 6, 9 and 10 exhibited cyctotoxicity against several tumor cells.

Original languageEnglish
Pages (from-to)10619-10626
Number of pages8
Issue number47
StatePublished - 15 Nov 2004


  • Cytotoxicity
  • HIV-1 RT inhibition
  • Lendenfeldia
  • Marine sponges
  • Sesterterpenes


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