New sesterterpenes from Madagascan Lendenfeldia sponges

Liat Chill; Amira Rudi; Maurice Aknin; Shoshana Loya; Amnon Hizi; Yoel Kashman

doi:10.1016/j.tet.2004.09.022

New sesterterpenes from Madagascan Lendenfeldia sponges

Liat Chill, Amira Rudi, Maurice Aknin, Shoshana Loya, Amnon Hizi, Yoel Kashman

Research output: Contribution to journal › Article › peer-review

Abstract

A new furanoterpene designated dehydrofurodendin and nine scalarane sesterterpenes of which four are new, were isolated from two different species of Madagascan sponges of the genus Lendenfeldia, both of which seem to be yet undescribed. The structure of the compounds was elucidated by interpretation of 1D and 2D NMR data. Dehydrofurodendin was found to be a potent inhibitor of HIV-1 RT. Several of the isolated scalaranes exhibited cyctotoxicity against several human tumor cells. A new furanoterpene (1), and nine scalarane sesterterpenes, of which four (2, 6-8) are new, were isolated from Madagascan Lendenfeldia sponges. Compound 1 was found to be a potent inhibitor of HIV-1 RT. Compounds 2, 6, 9 and 10 exhibited cyctotoxicity against several tumor cells.

Original language	English
Pages (from-to)	10619-10626
Number of pages	8
Journal	Tetrahedron
Volume	60
Issue number	47
DOIs	https://doi.org/10.1016/j.tet.2004.09.022
State	Published - 15 Nov 2004

Keywords

Cytotoxicity
HIV-1 RT inhibition
Lendenfeldia
Marine sponges
Sesterterpenes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tet.2004.09.022

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title = "New sesterterpenes from Madagascan Lendenfeldia sponges",

abstract = "A new furanoterpene designated dehydrofurodendin and nine scalarane sesterterpenes of which four are new, were isolated from two different species of Madagascan sponges of the genus Lendenfeldia, both of which seem to be yet undescribed. The structure of the compounds was elucidated by interpretation of 1D and 2D NMR data. Dehydrofurodendin was found to be a potent inhibitor of HIV-1 RT. Several of the isolated scalaranes exhibited cyctotoxicity against several human tumor cells. A new furanoterpene (1), and nine scalarane sesterterpenes, of which four (2, 6-8) are new, were isolated from Madagascan Lendenfeldia sponges. Compound 1 was found to be a potent inhibitor of HIV-1 RT. Compounds 2, 6, 9 and 10 exhibited cyctotoxicity against several tumor cells.",

keywords = "Cytotoxicity, HIV-1 RT inhibition, Lendenfeldia, Marine sponges, Sesterterpenes",

author = "Liat Chill and Amira Rudi and Maurice Aknin and Shoshana Loya and Amnon Hizi and Yoel Kashman",

year = "2004",

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doi = "10.1016/j.tet.2004.09.022",

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AU - Chill, Liat

AU - Rudi, Amira

AU - Aknin, Maurice

AU - Loya, Shoshana

AU - Hizi, Amnon

AU - Kashman, Yoel

PY - 2004/11/15

Y1 - 2004/11/15

N2 - A new furanoterpene designated dehydrofurodendin and nine scalarane sesterterpenes of which four are new, were isolated from two different species of Madagascan sponges of the genus Lendenfeldia, both of which seem to be yet undescribed. The structure of the compounds was elucidated by interpretation of 1D and 2D NMR data. Dehydrofurodendin was found to be a potent inhibitor of HIV-1 RT. Several of the isolated scalaranes exhibited cyctotoxicity against several human tumor cells. A new furanoterpene (1), and nine scalarane sesterterpenes, of which four (2, 6-8) are new, were isolated from Madagascan Lendenfeldia sponges. Compound 1 was found to be a potent inhibitor of HIV-1 RT. Compounds 2, 6, 9 and 10 exhibited cyctotoxicity against several tumor cells.

AB - A new furanoterpene designated dehydrofurodendin and nine scalarane sesterterpenes of which four are new, were isolated from two different species of Madagascan sponges of the genus Lendenfeldia, both of which seem to be yet undescribed. The structure of the compounds was elucidated by interpretation of 1D and 2D NMR data. Dehydrofurodendin was found to be a potent inhibitor of HIV-1 RT. Several of the isolated scalaranes exhibited cyctotoxicity against several human tumor cells. A new furanoterpene (1), and nine scalarane sesterterpenes, of which four (2, 6-8) are new, were isolated from Madagascan Lendenfeldia sponges. Compound 1 was found to be a potent inhibitor of HIV-1 RT. Compounds 2, 6, 9 and 10 exhibited cyctotoxicity against several tumor cells.

KW - Cytotoxicity

KW - HIV-1 RT inhibition

KW - Lendenfeldia

KW - Marine sponges

KW - Sesterterpenes

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JO - Tetrahedron

JF - Tetrahedron

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ER -

New sesterterpenes from Madagascan Lendenfeldia sponges

Abstract

Keywords

UN SDGs

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