New reproductive techniques

María Bustillo, Edward F. Fugger, Joseph D. Schulman, Nanette F. Santoro, Carol Gagliardi, Jose Colon, Jacquelyn Loughlin, Susan Wolf, Gerson Weiss, Cecilia Schmidt, John A. Robertson, David Levran, Jehoshua Dor, Izhar Ben-Shlomo, Shlomo Mashiach, Mark V. Sauer, Richard J. Paulson, Rogerio A. Lobo

Research output: Contribution to journalLetterpeer-review


To the Editor: We are concerned that the study by Levran et al. (Oct. 25, 1990, issue)1 suggests an inappropriately negative view of the value of embryo cryopreservation associated with in vitro fertilization. The reported results could have been influenced by numerous factors, including random variation, a suboptimal technique of freezing, and the use of infertile women as oocyte donors. A certain percentage of embryos do not, of course, survive cryopreservation. However, survival as evidenced by cleavage of zygotes frozen and thawed (n = 639) or by preservation of at least 50 percent of the blastomeres of cleaved embryos frozen.

Original languageEnglish
Pages (from-to)1043-1045
Number of pages3
JournalNew England Journal of Medicine
Issue number14
StatePublished - 3 Oct 1991
Externally publishedYes


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