New-onset post-transplantation food allergy in children - Is it attributable only to the immunosuppressive protocol?

Yael Levy*, Miriam Davidovits, Roxana Cleper, Rivka Shapiro

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

New-onset post-transplantation food allergy has been described mainly after liver transplantation, and its pathogenesis was attributed to the immunomodulatory effects of tacrolimus therapy. The aim of the present study was to evaluate the association of food allergy with solid organ transplantation in our center. The medical records of children who underwent kidney transplantation and children who underwent liver or liver and kidney transplantation from 1986 to 2005 were reviewed. A total of 189 children (124 after kidney transplantation, 65 after liver or liver and kidney transplantation) received tacrolimus as part of the immunosuppressive regimen. New-onset post-transplantation food allergy was documented in four of them: two with liver transplants and two with combined kidney and liver transplants. The absence of new-onset food allergy in the children with isolated kidney transplants is compatible with other reports in the literature. This study supports the concept that the functioning liver itself, and not only tacrolimus immunosuppression, is a main contributor to food allergy in this patient population.

Original languageEnglish
Pages (from-to)63-69
Number of pages7
JournalPediatric Transplantation
Volume13
Issue number1
DOIs
StatePublished - Feb 2009

Keywords

  • Children
  • Food allergy
  • Kidney
  • Liver
  • Tacrolimus
  • Transplantation

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