New noninvasive index for evaluation of the vascular age of healthy and sick people

Ilya Fine*, Boris I. Kuznik, Alexander V. KuznikKaminsky, Louis Shenkman, Evgeniya M. Kustovsjya, Olga G. Maximova

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


We conducted a study on 861 healthy and sick subjects and demonstrated that some calculated parameters based on measurement of the dynamic light scattering (DLS) signal from the finger correlate highly with chronological age ranging from 1.5 to 85 years old. Measurements of DLS signals were obtained during both occlusion and nonocclusion of blood flow in the finger. For the nonocclusion case we found that the low-frequency component of the DLS signal significantly correlates with the biological age while the high-frequency component of the DLS signal resembles the arterial pulse-wave and does correlate with age. However, the most prominent correlation between the DLS characteristics and age was noted with the stasis stage measurements. We propose that the observed age-related phenomena are caused by alterations in local blood viscosity and interactions of the endothelial cells with erythrocytes. Further, a new noninvasive index based on the age-related optical characteristics was introduced. This noninvasive index may be used as a research and diagnostic tool to examine the endothelial and thrombolytic properties of the vascular system.

Original languageEnglish
Article number087002
JournalJournal of Biomedical Optics
Issue number8
StatePublished - Aug 2012


  • Blood viscosity
  • Coagulation
  • Dynamic light scattering
  • Endothelial cells
  • Erythrocytes
  • Pulse wave


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