New MRI method with contrast based on the macromolecular characteristics of tissues

Arnon Neufeld; Uzi Eliav; Gil Navon

doi:10.1002/mrm.10546

New MRI method with contrast based on the macromolecular characteristics of tissues

Arnon Neufeld, Uzi Eliav, Gil Navon^*

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A new MRI method with a contrast that is derived from the macromolecular composition and spin dynamics in the tissue is described and demonstrated on excised mouse brain and rat spinal cord. In the method, magnetization is selectively excited in the macromolecules by using a double quantum filter and subsequently transferred to water. The new imaging method differs from previous methods that rely on magnetization transfer contrast (MTC) in that it enables a separate and independent control of the effect of the macromolecule characteristics, chemical exchange, and water-related parameters on the images.

Original language	English
Pages (from-to)	229-234
Number of pages	6
Journal	Magnetic Resonance in Medicine
Volume	50
Issue number	2
DOIs	https://doi.org/10.1002/mrm.10546
State	Published - 1 Aug 2003

Keywords

Brain imaging
Double quantum filtered NMR
MRI
Magnetization transfer

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10.1002/mrm.10546

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New MRI method with contrast based on the macromolecular characteristics of tissues

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Keywords

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