New MRI method with contrast based on the macromolecular characteristics of tissues

Arnon Neufeld, Uzi Eliav, Gil Navon

Research output: Contribution to journalArticlepeer-review

Abstract

A new MRI method with a contrast that is derived from the macromolecular composition and spin dynamics in the tissue is described and demonstrated on excised mouse brain and rat spinal cord. In the method, magnetization is selectively excited in the macromolecules by using a double quantum filter and subsequently transferred to water. The new imaging method differs from previous methods that rely on magnetization transfer contrast (MTC) in that it enables a separate and independent control of the effect of the macromolecule characteristics, chemical exchange, and water-related parameters on the images.

Original languageEnglish
Pages (from-to)229-234
Number of pages6
JournalMagnetic Resonance in Medicine
Volume50
Issue number2
DOIs
StatePublished - 1 Aug 2003

Keywords

  • Brain imaging
  • Double quantum filtered NMR
  • MRI
  • Magnetization transfer

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