New modes in label-free super resolution based on photo-modulated reflectivity

O. Tzang, O. Cheshnovsky

Research output: Contribution to journalArticlepeer-review


The recent advances in far-field super-resolution (SR) microscopy rely on, and therefore are limited by the ability to control the fluorescence of label molecules. We demonstrated a far field label-free SR methodology that relies on the nonlinear response of the reflectance to photo-modulation by a pump laser. Here we extend our approach in two directions. We show that the method can be further simplified and improved by using a single beam rather than a pump and probe or by adding spatial probe modulation to improve resolution. Additionally, we demonstrate SR in sectioning and further investigate the dynamics of nonlinearity in photo-modulated reflectance. These new modalities of nonlinear photo-modulated reflectivity (NPMR) enhance its applicability using lower orders of nonlinear response.

Original languageEnglish
Pages (from-to)20926-20932
Number of pages7
JournalOptics Express
Issue number16
StatePublished - 10 Aug 2015


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