Abstract
The recent advances in far-field super-resolution (SR) microscopy rely on, and therefore are limited by the ability to control the fluorescence of label molecules. We demonstrated a far field label-free SR methodology that relies on the nonlinear response of the reflectance to photo-modulation by a pump laser. Here we extend our approach in two directions. We show that the method can be further simplified and improved by using a single beam rather than a pump and probe or by adding spatial probe modulation to improve resolution. Additionally, we demonstrate SR in sectioning and further investigate the dynamics of nonlinearity in photo-modulated reflectance. These new modalities of nonlinear photo-modulated reflectivity (NPMR) enhance its applicability using lower orders of nonlinear response.
Original language | English |
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Pages (from-to) | 20926-20932 |
Number of pages | 7 |
Journal | Optics Express |
Volume | 23 |
Issue number | 16 |
DOIs | |
State | Published - 10 Aug 2015 |