TY - JOUR
T1 - New model-based indices for maximum expiratory flow-volume curve in patients with chronic obstructive pulmonary disease
AU - Barnea, Ofer
AU - Abboud, Shimon
AU - Guber, Alexander
AU - Bruderman, Israel
PY - 1996/3
Y1 - 1996/3
N2 - New lung function indices based on a lumped parameter model of the maximal expiratory flow-volume (MEFV) curve are presented. The waveforms obtained by the model were compared to the flow-volume curves recorded from normal subjects and from patients with small airways disease, asthma and emphysema. We were able to reproduce the flow-volume curves using the model and calculate new parameters that indicate the degree of lung function impairment and may be applicable to identify mild chronic obstructive pulmonary diseases. Further studies in larger groups of patients are required to better define the true predictive value of the new indices described for the diagnosis of COPD.
AB - New lung function indices based on a lumped parameter model of the maximal expiratory flow-volume (MEFV) curve are presented. The waveforms obtained by the model were compared to the flow-volume curves recorded from normal subjects and from patients with small airways disease, asthma and emphysema. We were able to reproduce the flow-volume curves using the model and calculate new parameters that indicate the degree of lung function impairment and may be applicable to identify mild chronic obstructive pulmonary diseases. Further studies in larger groups of patients are required to better define the true predictive value of the new indices described for the diagnosis of COPD.
KW - Forced vital capacity test
KW - Lung function parameters
KW - Mathematical models
KW - Maximum expiratory flow-volume
KW - Respiration
UR - http://www.scopus.com/inward/record.url?scp=0030111453&partnerID=8YFLogxK
U2 - 10.1016/0010-4825(95)00050-X
DO - 10.1016/0010-4825(95)00050-X
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AN - SCOPUS:0030111453
SN - 0010-4825
VL - 26
SP - 123
EP - 131
JO - Computers in Biology and Medicine
JF - Computers in Biology and Medicine
IS - 2
ER -
