New method for remote and repeatable monitoring of intraocular pressure variations

Israel Margalit, Yevgeny Beiderman, Alon Skaat, Elkanah Rosenfeld, Michael Belkin, Ralf Peter Tornow, Vicente Mico*, Javier Garcia, Zeev Zalevsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

We present initial steps toward a new measurement device enabling high-precision, noncontact remote and repeatable monitoring of intraocular pressure (IOP)-based on an innovative measurement principle. Using only a camera and a laser source, the device measures IOP by tracking the secondary speckle pattern trajectories produced by the reflection of an illuminating laser beam from the iris or the sclera. The device was tested on rabbit eyes using two different methods to modify IOP: via an infusion bag and via mechanical pressure. In both cases, the eyes were stimulated with increasing and decreasing ramps of the IOP. As IOP variations changed the speckle distributions reflected back from the eye, data were recorded under various optical configurations to define and optimize the best experimental configuration for the IOP extraction. The association between the data provided by our proposed device and that resulting from controlled modification of the IOP was assessed, revealing high correlation (R2 = 0.98) and sensitivity and providing a high-precision measurement (5% estimated error) for the best experimental configuration. Future steps will be directed toward applying the proposed measurement principle in clinical trials for monitoring IOP with human subjects.

Original languageEnglish
Article number027002
JournalJournal of Biomedical Optics
Volume19
Issue number2
DOIs
StatePublished - Feb 2014

Funding

FundersFunder number
Ministerio de Economía y Competitividad
European Regional Development FundFIS2010-16646

    Keywords

    • Intraocular pressure
    • Intraocular pressure fluctuation
    • Remote sensing technology

    Fingerprint

    Dive into the research topics of 'New method for remote and repeatable monitoring of intraocular pressure variations'. Together they form a unique fingerprint.

    Cite this