New insights into associated co-morbidities in patients with cutaneous T-cell lymphoma (mycosis fungoides)

Emmilia Hodak, Stuart Lessin, Rivka Friedland, Tamar Freud, Michael David, Lev Pavlovsky, Jonathan Shapiro, Arnon D. Cohen

Research output: Contribution to journalArticlepeer-review

Abstract

Studies of associated cancer in patients with mycosis fungoides (MF) have focused primarily on secondary cancers in North American and European populations. This study investigated the association between MF and malignancies, anxiety and depression in the Israeli population. Data on Israeli patients with MF and age- and gender-matched controls were collected from a database of population- based cohort (683 patients; 1,700 controls) and an institution- based cohort (343 patients; 846 controls) and analysed by univariate and multivariate methods. MF was significantly associated with Hodgkin's lymphoma in both cohorts (multivariate odds ratio (OR) 7.83, univariate OR ∞, respectively); acute leukaemia (multivariate OR 10.1, first cohort) and lung cancer (multivariate OR 10.15, second cohort). MF was significantly associated with anxiety and depression (multivariate OR 1.59, OR 1.51, respectively in first cohort). The current study provides support to the associations between MF and other cancers: Hodgkin's lymphoma, acute leukaemia and lung cancer. The study also emphasizes the association between MF and anxiety and depression.

Original languageEnglish
Pages (from-to)451-455
Number of pages5
JournalActa Dermato-Venereologica
Volume93
Issue number4
DOIs
StatePublished - 2013

Keywords

  • Acute leukaemia
  • Anxiety
  • Cutaneous T-cell lymphoma
  • Depression
  • Hodgkin's lymphoma
  • Lung cancer
  • Mycosis fungoides

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