TY - JOUR
T1 - New hallmarks of ageing
T2 - a 2022 Copenhagen ageing meeting summary
AU - Schmauck-Medina, Tomas
AU - Molière, Adrian
AU - Lautrup, Sofie
AU - Zhang, Jianying
AU - Chlopicki, Stefan
AU - Madsen, Helena Borland
AU - Cao, Shuqin
AU - Soendenbroe, Casper
AU - Mansell, Els
AU - Vestergaard, Mark Bitsch
AU - Li, Zhiquan
AU - Shiloh, Yosef
AU - Opresko, Patricia L.
AU - Egly, Jean Marc
AU - Kirkwood, Thomas
AU - Verdin, Eric
AU - Bohr, Vilhelm A.
AU - Cox, Lynne S.
AU - Stevnsner, Tinna
AU - Rasmussen, Lene Juel
AU - Fang, Evandro F.
N1 - Publisher Copyright:
© 2022 Schmauck-Medina et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2022
Y1 - 2022
N2 - Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication were the original nine hallmarks of ageing proposed by López-Otín and colleagues in 2013. The proposal of these hallmarks of ageing has been instrumental in guiding and pushing forward research on the biology of ageing. In the nearly past 10 years, our in-depth exploration on ageing research has enabled us to formulate new hallmarks of ageing which are compromised autophagy, microbiome disturbance, altered mechanical properties, splicing dysregulation, and inflammation, among other emerging ones. Amalgamation of the ‘old’ and ‘new’ hallmarks of ageing may provide a more comprehensive explanation of ageing and age-related diseases, shedding light on interventional and therapeutic studies to achieve healthy, happy, and productive lives in the elderly.
AB - Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication were the original nine hallmarks of ageing proposed by López-Otín and colleagues in 2013. The proposal of these hallmarks of ageing has been instrumental in guiding and pushing forward research on the biology of ageing. In the nearly past 10 years, our in-depth exploration on ageing research has enabled us to formulate new hallmarks of ageing which are compromised autophagy, microbiome disturbance, altered mechanical properties, splicing dysregulation, and inflammation, among other emerging ones. Amalgamation of the ‘old’ and ‘new’ hallmarks of ageing may provide a more comprehensive explanation of ageing and age-related diseases, shedding light on interventional and therapeutic studies to achieve healthy, happy, and productive lives in the elderly.
KW - Autophagy
KW - Hallmarks of ageing
KW - Healthspan
KW - Longevity
KW - Neurodegeneration
UR - http://www.scopus.com/inward/record.url?scp=85137298030&partnerID=8YFLogxK
U2 - 10.18632/aging.204248
DO - 10.18632/aging.204248
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C2 - 36040386
AN - SCOPUS:85137298030
SN - 1945-4589
VL - 14
SP - 6829
EP - 6839
JO - Aging
JF - Aging
IS - 16
ER -