@article{e4cf4f22d773441cba67e78c634afc5c,
title = "New epiphyseal stippling syndrome with osteoclastic hyperplasia",
abstract = "We present a lethal skeletal dysplasia characterized radiographically by severe stippling of the lower spine and long bones and periosteal cloaking. In contrast to the normal morphology of the epiphyses and growth plates, the marrow was filled with loose fibrous tissue containing numerous large multinucleated osteoclasts which were associated with Howship's lacunae on the endosteal surface. We suggest the term 'Pacman dysplasia' to describe this unusual histologic change that characterizes this new bone dysplasia.",
keywords = "Pacman syndrome, epiphyseal stippling, osteoclast hyperplasia, skeletal dysplasia",
author = "M. Shohat and Rimoin, {D. L.} and Gruber, {H. E.} and R. Lachman",
year = "1993",
doi = "10.1002/ajmg.1320450506",
language = "אנגלית",
volume = "45",
pages = "558--561",
journal = "American Journal of Medical Genetics",
issn = "0148-7299",
publisher = "Wiley-Liss Inc.",
number = "5",
}