New drug targets for depression and anxiety: Is the peptides era arriving?

David Gurwitz; Avraham Weizman

doi:10.1002/ddr.20012

New drug targets for depression and anxiety: Is the peptides era arriving?

David Gurwitz^*, Avraham Weizman

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

The monoamine theory of mood disorders has dominated psychiatric dogma for nearly 50 years. Recent findings about the role of brain peptides in the regulation of emotions and behavior challenge this over-simplified theory, and are about to open the door for a new era, focused on peptides as putative complementary drug targets in psychiatry. The development of improved animal models for depression would accelerate its arrival.

Original language	English
Pages (from-to)	93-96
Number of pages	4
Journal	Drug Development Research
Volume	65
Issue number	3
DOIs	https://doi.org/10.1002/ddr.20012
State	Published - Jul 2005

Keywords

Angiotensin
Animal models
Clinical trials
Corticotropin-releasing factor type-1 receptor
Galanin
Melanin-concentrating hormone receptors
Monoamines
Neuropeptide Y
Pharmacogenetics
Vasopressin

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10.1002/ddr.20012

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KW - Neuropeptide Y

KW - Pharmacogenetics

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New drug targets for depression and anxiety: Is the peptides era arriving?

Abstract

Keywords

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