New concepts in regulation and function of the insulin-like growth factors: Implications for understanding normal growth and neoplasia

H. Werner, D. Le Roith

Research output: Contribution to journalReview articlepeer-review

Abstract

The insulin-like growth factors (IGFs) are a ubiquitous family of growth factors, binding proteins and receptors that are involved in normal growth and development. They are also implicated in numerous pathological states, including malignancy. IGF-II is a commonly expressed growth factor in many tumors and may enhance tumor growth, acting via the overexpressed IGF-I receptor, a cell-surface tyrosine kinase receptor. The IGF-I receptor may be overexpressed due to mutations in tumor suppression gene products such as p53 and WT-1 or growth factors such as bFGF and PDGF. Thus, this family of growth factors, especially the IGF-I receptor, may present an excellent target for new therapeutic agents in the treatment of cancer and other disorders of excessive cellular proliferation.

Original languageEnglish
Pages (from-to)932-942
Number of pages11
JournalCellular and Molecular Life Sciences
Volume57
Issue number6
DOIs
StatePublished - 2000

Keywords

  • Cancer
  • IGF-I receptor
  • Insulin-like growth factors
  • Receptor signaling

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