New complex Ph'translocation t (10; 14; 22) in bone marrow cells and in PHA-stimulated peripheral blood cultures in chronic myelocytic leukaemia

F. Shabtai; U. Gafter; S. Weiss; M. Djaldetti; I. Halbrecht

doi:10.1007/BF00408101

New complex Ph'translocation t (10; 14; 22) in bone marrow cells and in PHA-stimulated peripheral blood cultures in chronic myelocytic leukaemia

F. Shabtai, U. Gafter, S. Weiss, M. Djaldetti, I. Halbrecht^*

^*Corresponding author for this work

Clinical Departments

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Abstract

A patient with chronic myelocytic leukaemia (CML) and a new complex Philadelphia chromosome (Ph') translocation, t (10; 14; 22), is described. This three way Ph' translocation not involving chromosome 9 was present in the majority of the bone marrow cells, as well as in a great proportion of metaphases from phytohaemagglutinin (PHA) stimulated peripheral blood cultures. The possibility that the Ph' translocation was present also in lymphocytes is discussed and at this regard the involvement of chromosome 14 is of interest considering the documented non random involvement of chromosome 14 in lymphoid malignancies.

Original language	English
Pages (from-to)	287-294
Number of pages	8
Journal	Journal of Cancer Research and Clinical Oncology
Volume	96
Issue number	3
DOIs	https://doi.org/10.1007/BF00408101
State	Published - Apr 1980

Keywords

Blood Cultures
Bone Marrow Cells
Chronic Myelocytic Leukaemia
PHA

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10.1007/BF00408101

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title = "New complex Ph'translocation t (10; 14; 22) in bone marrow cells and in PHA-stimulated peripheral blood cultures in chronic myelocytic leukaemia",

abstract = "A patient with chronic myelocytic leukaemia (CML) and a new complex Philadelphia chromosome (Ph') translocation, t (10; 14; 22), is described. This three way Ph' translocation not involving chromosome 9 was present in the majority of the bone marrow cells, as well as in a great proportion of metaphases from phytohaemagglutinin (PHA) stimulated peripheral blood cultures. The possibility that the Ph' translocation was present also in lymphocytes is discussed and at this regard the involvement of chromosome 14 is of interest considering the documented non random involvement of chromosome 14 in lymphoid malignancies.",

keywords = "Blood Cultures, Bone Marrow Cells, Chronic Myelocytic Leukaemia, PHA",

author = "F. Shabtai and U. Gafter and S. Weiss and M. Djaldetti and I. Halbrecht",

year = "1980",

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AU - Shabtai, F.

AU - Gafter, U.

AU - Weiss, S.

AU - Djaldetti, M.

AU - Halbrecht, I.

PY - 1980/4

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N2 - A patient with chronic myelocytic leukaemia (CML) and a new complex Philadelphia chromosome (Ph') translocation, t (10; 14; 22), is described. This three way Ph' translocation not involving chromosome 9 was present in the majority of the bone marrow cells, as well as in a great proportion of metaphases from phytohaemagglutinin (PHA) stimulated peripheral blood cultures. The possibility that the Ph' translocation was present also in lymphocytes is discussed and at this regard the involvement of chromosome 14 is of interest considering the documented non random involvement of chromosome 14 in lymphoid malignancies.

AB - A patient with chronic myelocytic leukaemia (CML) and a new complex Philadelphia chromosome (Ph') translocation, t (10; 14; 22), is described. This three way Ph' translocation not involving chromosome 9 was present in the majority of the bone marrow cells, as well as in a great proportion of metaphases from phytohaemagglutinin (PHA) stimulated peripheral blood cultures. The possibility that the Ph' translocation was present also in lymphocytes is discussed and at this regard the involvement of chromosome 14 is of interest considering the documented non random involvement of chromosome 14 in lymphoid malignancies.

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KW - Bone Marrow Cells

KW - Chronic Myelocytic Leukaemia

KW - PHA

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JO - Journal of Cancer Research and Clinical Oncology

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ER -

New complex Ph'translocation t (10; 14; 22) in bone marrow cells and in PHA-stimulated peripheral blood cultures in chronic myelocytic leukaemia

Abstract

Keywords

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