TY - JOUR
T1 - New Analgesic Drugs Derived from Phencyclidine
AU - Itzhak, Yossef
AU - Kalir, Asher
AU - Weissman, Ben Avi
AU - Cohen, Sasson
PY - 1981/5
Y1 - 1981/5
N2 - Several esters of 1-(1-phenylcyclohexyl)-4-piperidinol (3), 1-(1-phenylcyclohexyl)-4-phenyl-4-piperidinol (10) and its propionate (11), and 1-(1 -phenylcyclohexyl)-4-phenylpiperidine (13) were prepared and characterized. The new compounds, which are derived from phencyclidine, exerted analgesic activity in mice. The most potent is 10, which is twice as active as morphine. The antinociceptive activity of 10,11, and 13 could be well correlated with their potency in the mouse vas deferens bioassay, and both were completely reversed by naloxone.
AB - Several esters of 1-(1-phenylcyclohexyl)-4-piperidinol (3), 1-(1-phenylcyclohexyl)-4-phenyl-4-piperidinol (10) and its propionate (11), and 1-(1 -phenylcyclohexyl)-4-phenylpiperidine (13) were prepared and characterized. The new compounds, which are derived from phencyclidine, exerted analgesic activity in mice. The most potent is 10, which is twice as active as morphine. The antinociceptive activity of 10,11, and 13 could be well correlated with their potency in the mouse vas deferens bioassay, and both were completely reversed by naloxone.
UR - http://www.scopus.com/inward/record.url?scp=0019796168&partnerID=8YFLogxK
U2 - 10.1021/jm00137a004
DO - 10.1021/jm00137a004
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C2 - 7241506
AN - SCOPUS:0019796168
VL - 24
SP - 496
EP - 499
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
SN - 0022-2623
IS - 5
ER -