Never resting region - mPFC in schizophrenia

Maya Bleich-Cohen; Marina Kupchik; Michal Gruberger; Moshe Kotler; Talma Hendler

doi:10.1016/j.schres.2012.06.030

Never resting region - mPFC in schizophrenia

Maya Bleich-Cohen^*, Marina Kupchik, Michal Gruberger, Moshe Kotler, Talma Hendler

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Reduced functional connectivity (FC) in schizophrenia has been demonstrated either in task related or 'default network' areas, but not between these networks, which interact meaningfully. We examined the role of FC between the inferior frontal gyrus (IFG) and medial prefrontal cortex (mPFC) in determining language-lateralization during a language task, and its association with structural integrity of the corpus-callosum. Only schizophrenia patients presented increased mPFC-IFG FC during task, which additionally corresponded to decreased white-matter organization of the corpus-callosum. These findings suggest that inability to suppress irrelevant internally-generated information while processing external stimuli might be the basis of functional psychopathology in schizophrenia.

Original language	English
Pages (from-to)	155-158
Number of pages	4
Journal	Schizophrenia Research
Volume	140
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2012.06.030
State	Published - Sep 2012

Keywords

DMN
FMRI
Language
Schizophrenia

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10.1016/j.schres.2012.06.030

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title = "Never resting region - mPFC in schizophrenia",

abstract = "Reduced functional connectivity (FC) in schizophrenia has been demonstrated either in task related or 'default network' areas, but not between these networks, which interact meaningfully. We examined the role of FC between the inferior frontal gyrus (IFG) and medial prefrontal cortex (mPFC) in determining language-lateralization during a language task, and its association with structural integrity of the corpus-callosum. Only schizophrenia patients presented increased mPFC-IFG FC during task, which additionally corresponded to decreased white-matter organization of the corpus-callosum. These findings suggest that inability to suppress irrelevant internally-generated information while processing external stimuli might be the basis of functional psychopathology in schizophrenia.",

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AB - Reduced functional connectivity (FC) in schizophrenia has been demonstrated either in task related or 'default network' areas, but not between these networks, which interact meaningfully. We examined the role of FC between the inferior frontal gyrus (IFG) and medial prefrontal cortex (mPFC) in determining language-lateralization during a language task, and its association with structural integrity of the corpus-callosum. Only schizophrenia patients presented increased mPFC-IFG FC during task, which additionally corresponded to decreased white-matter organization of the corpus-callosum. These findings suggest that inability to suppress irrelevant internally-generated information while processing external stimuli might be the basis of functional psychopathology in schizophrenia.

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Never resting region - mPFC in schizophrenia

Abstract

Keywords

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