Never resting region - mPFC in schizophrenia

Maya Bleich-Cohen; Marina Kupchik; Michal Gruberger; Moshe Kotler; Talma Hendler

doi:10.1016/j.schres.2012.06.030

Never resting region - mPFC in schizophrenia

Maya Bleich-Cohen^*, Marina Kupchik, Michal Gruberger, Moshe Kotler, Talma Hendler

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Reduced functional connectivity (FC) in schizophrenia has been demonstrated either in task related or 'default network' areas, but not between these networks, which interact meaningfully. We examined the role of FC between the inferior frontal gyrus (IFG) and medial prefrontal cortex (mPFC) in determining language-lateralization during a language task, and its association with structural integrity of the corpus-callosum. Only schizophrenia patients presented increased mPFC-IFG FC during task, which additionally corresponded to decreased white-matter organization of the corpus-callosum. These findings suggest that inability to suppress irrelevant internally-generated information while processing external stimuli might be the basis of functional psychopathology in schizophrenia.

Original language	English
Pages (from-to)	155-158
Number of pages	4
Journal	Schizophrenia Research
Volume	140
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2012.06.030
State	Published - Sep 2012

Keywords

DMN
FMRI
Language
Schizophrenia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.schres.2012.06.030

Cite this

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title = "Never resting region - mPFC in schizophrenia",

abstract = "Reduced functional connectivity (FC) in schizophrenia has been demonstrated either in task related or 'default network' areas, but not between these networks, which interact meaningfully. We examined the role of FC between the inferior frontal gyrus (IFG) and medial prefrontal cortex (mPFC) in determining language-lateralization during a language task, and its association with structural integrity of the corpus-callosum. Only schizophrenia patients presented increased mPFC-IFG FC during task, which additionally corresponded to decreased white-matter organization of the corpus-callosum. These findings suggest that inability to suppress irrelevant internally-generated information while processing external stimuli might be the basis of functional psychopathology in schizophrenia.",

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author = "Maya Bleich-Cohen and Marina Kupchik and Michal Gruberger and Moshe Kotler and Talma Hendler",

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doi = "10.1016/j.schres.2012.06.030",

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AU - Bleich-Cohen, Maya

AU - Kupchik, Marina

AU - Gruberger, Michal

AU - Kotler, Moshe

AU - Hendler, Talma

PY - 2012/9

Y1 - 2012/9

N2 - Reduced functional connectivity (FC) in schizophrenia has been demonstrated either in task related or 'default network' areas, but not between these networks, which interact meaningfully. We examined the role of FC between the inferior frontal gyrus (IFG) and medial prefrontal cortex (mPFC) in determining language-lateralization during a language task, and its association with structural integrity of the corpus-callosum. Only schizophrenia patients presented increased mPFC-IFG FC during task, which additionally corresponded to decreased white-matter organization of the corpus-callosum. These findings suggest that inability to suppress irrelevant internally-generated information while processing external stimuli might be the basis of functional psychopathology in schizophrenia.

AB - Reduced functional connectivity (FC) in schizophrenia has been demonstrated either in task related or 'default network' areas, but not between these networks, which interact meaningfully. We examined the role of FC between the inferior frontal gyrus (IFG) and medial prefrontal cortex (mPFC) in determining language-lateralization during a language task, and its association with structural integrity of the corpus-callosum. Only schizophrenia patients presented increased mPFC-IFG FC during task, which additionally corresponded to decreased white-matter organization of the corpus-callosum. These findings suggest that inability to suppress irrelevant internally-generated information while processing external stimuli might be the basis of functional psychopathology in schizophrenia.

KW - DMN

KW - FMRI

KW - Language

KW - Schizophrenia

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DO - 10.1016/j.schres.2012.06.030

M3 - מאמר

AN - SCOPUS:84865316893

VL - 140

SP - 155

EP - 158

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

IS - 1-3

ER -

Never resting region - mPFC in schizophrenia

Abstract

Keywords

UN SDGs

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