TY - JOUR
T1 - Neutrophil-to-Lymphocyte Ratio as a Prognostic Marker in Transcatheter Aortic Valve Implantation (TAVI) Patients
AU - Merdler, Ilan
AU - Frydman, Shir
AU - Sirota, Svetlana
AU - Halkin, Amir
AU - Steinvil, Arie
AU - Toledano, Ella
AU - Konigstein, Maayan
AU - Litmanowicz, Batia
AU - Bazan, Samuel
AU - Wenkert, Atalia
AU - Sadon, Sapir
AU - Banai, Shmuel
AU - Finkelstein, Ariel
AU - Arbel, Yaron
N1 - Publisher Copyright:
© 2022 Israel Medical Association. All rights reserved.
PY - 2022/4
Y1 - 2022/4
N2 - Background: Neutrophil-to-lymphocyte ratio (NLR) is a simple and cost-effective marker of inflammation. This marker has been shown to predict cardiac arrhythmias, progression of valvular heart disease, congestive heart failure decompensation, acute kidney injury, and mortality in cardiovascular patients. The pathologic process of aortic stenosis includes chronic inflammation of the valve and therefore biomarkers of inflammation might offer additive prognostic value. Objectives: To evaluate NLR and its association with long-term mortality in transcatheter aortic valve implantation (TAVI) patients. Methods: We evaluated data of 1152 consecutive patient from the Tel Aviv Medical Center TAVI registry who underwent TAVI. Data included baseline clinical, demographic, and echocardiography findings; procedural complications; and post-procedure mortality. Patients were compared by using the median NLR value (4.1) and evaluated for long-term mortality. Results: Patients with NLR above the median had higher mortality rates (26.4% vs. 16.3%, P < 0.001) at 3 years post-procedure. A multivariate analysis found NLR to be an independent risk factor for mortality (hazard ratio = 1.47, 95% confidence interval 1.09-1.99, P= 0.013). In addition, high NLR was linked to complicationsduring and after the procedure. Conclusion: NLR is an independent prognostic marker among TAVI patients. This marker may represent an increased inflammatory response and should be added to previous known prognostic factors.
AB - Background: Neutrophil-to-lymphocyte ratio (NLR) is a simple and cost-effective marker of inflammation. This marker has been shown to predict cardiac arrhythmias, progression of valvular heart disease, congestive heart failure decompensation, acute kidney injury, and mortality in cardiovascular patients. The pathologic process of aortic stenosis includes chronic inflammation of the valve and therefore biomarkers of inflammation might offer additive prognostic value. Objectives: To evaluate NLR and its association with long-term mortality in transcatheter aortic valve implantation (TAVI) patients. Methods: We evaluated data of 1152 consecutive patient from the Tel Aviv Medical Center TAVI registry who underwent TAVI. Data included baseline clinical, demographic, and echocardiography findings; procedural complications; and post-procedure mortality. Patients were compared by using the median NLR value (4.1) and evaluated for long-term mortality. Results: Patients with NLR above the median had higher mortality rates (26.4% vs. 16.3%, P < 0.001) at 3 years post-procedure. A multivariate analysis found NLR to be an independent risk factor for mortality (hazard ratio = 1.47, 95% confidence interval 1.09-1.99, P= 0.013). In addition, high NLR was linked to complicationsduring and after the procedure. Conclusion: NLR is an independent prognostic marker among TAVI patients. This marker may represent an increased inflammatory response and should be added to previous known prognostic factors.
KW - aortic stenosis
KW - inflammatory markers
KW - neutrophil-to-lymphocyte ratio (NLR)
KW - transcatheter aortic valve implantation (TAVI)
UR - http://www.scopus.com/inward/record.url?scp=85128154757&partnerID=8YFLogxK
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C2 - 35415981
AN - SCOPUS:85128154757
SN - 1565-1088
VL - 24
SP - 229
EP - 234
JO - Israel Medical Association Journal
JF - Israel Medical Association Journal
IS - 4
ER -
