Neutralizing monoclonal antibodies against α and β subunits of the Ustilago maydis virus encoded toxin

I. Ginzberg; S. Rosenblum; Y. Koltin; N. I. Smorodinsky

doi:10.1007/BF01702565

Neutralizing monoclonal antibodies against α and β subunits of the Ustilago maydis virus encoded toxin

I. Ginzberg, S. Rosenblum, Y. Koltin^*, N. I. Smorodinsky

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The toxins secreted by Ustilago maydis are encoded by dsRNA viruses. The KP6 toxin encoded by subtype P6 consists of two polypeptides α and β, which are not covalently bound. Neutralizing monoclonal antibodies (MoAbs) were raised against each subunit. Some of the anti-β MoAbs identify different epitopes in the antigen. The MoAbs were used to affinity purify α and β polypeptides from culture media and to detect the precursor of the mature toxin.

Original language	English
Pages (from-to)	273-280
Number of pages	8
Journal	Virus Genes
Volume	6
Issue number	3
DOIs	https://doi.org/10.1007/BF01702565
State	Published - Aug 1992

Keywords

Ustilago maydis
dsRNA virus
fungal toxins
monoclonal antibodies

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10.1007/BF01702565

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abstract = "The toxins secreted by Ustilago maydis are encoded by dsRNA viruses. The KP6 toxin encoded by subtype P6 consists of two polypeptides α and β, which are not covalently bound. Neutralizing monoclonal antibodies (MoAbs) were raised against each subunit. Some of the anti-β MoAbs identify different epitopes in the antigen. The MoAbs were used to affinity purify α and β polypeptides from culture media and to detect the precursor of the mature toxin.",

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AU - Koltin, Y.

AU - Smorodinsky, N. I.

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AB - The toxins secreted by Ustilago maydis are encoded by dsRNA viruses. The KP6 toxin encoded by subtype P6 consists of two polypeptides α and β, which are not covalently bound. Neutralizing monoclonal antibodies (MoAbs) were raised against each subunit. Some of the anti-β MoAbs identify different epitopes in the antigen. The MoAbs were used to affinity purify α and β polypeptides from culture media and to detect the precursor of the mature toxin.

KW - Ustilago maydis

KW - dsRNA virus

KW - fungal toxins

KW - monoclonal antibodies

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Neutralizing monoclonal antibodies against α and β subunits of the Ustilago maydis virus encoded toxin

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Keywords

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