@article{932f671f4c844716ad8f256aa58c0ffe,
title = "Neurotrophin 4 enhances in vitro follicular assembly in human fetal ovaries",
abstract = "Objective: To investigate the in vitro effect of neurotrophin 4 (NT-4) on follicular assembly in human fetal ovaries. Design: Human ovarian tissue from fetuses at 19-20 gestational weeks was placed in organ culture for two weeks with NT-4. Control groups were cultured with a neutralizing antibody against NT-4. Setting: Infertility unit at an university-affiliated tertiary medical center. Patient(s): Four patients who underwent pregnancy terminations at 19-20 gestational weeks. Intervention(s): None. Main Outcome Measure(s): Histologic findings of follicular assembly. Result(s): Follicular assembly was significantly increased in the specimens cultured with NT-4 than in the uncultured specimens, the samples cultured without NT-4, and samples cultured with the neutralizing antibody. In the second week of culture, additional follicular assembly was promoted in the presence of 100 ng/mL NT-4 but not with 10 ng/mL NT-4. Conclusion(s): This is the first report showing that NT-4 seems to promote human follicular assembly in fetal ovaries, probably in a dose-dependent manner. Follicular assembly is regulated by multiple signals, and additional studies on the effects of other growth factors in combination with NT-4 are warranted.",
keywords = "Neurotrophin 4, human fetal ovaries, p75 receptor, primordial follicular assembly",
author = "Jacob Farhi and Benjamin Fisch and Roni Garor and Yoav Peled and Haim Pinkas and Ronit Abir",
note = "Funding Information: Supported, in part, by a research grant from the Israel Cancer Association . ",
year = "2011",
month = mar,
day = "15",
doi = "10.1016/j.fertnstert.2010.03.051",
language = "אנגלית",
volume = "95",
pages = "1267--1271",
journal = "Fertility and Sterility",
issn = "0015-0282",
publisher = "Elsevier Inc.",
number = "4",
}