TY - JOUR
T1 - Neurosteroid blood levels in delinquent adolescent boys with conduct disorder
AU - Golubchik, Pavel
AU - Mozes, Tamar
AU - Maayan, Rachel
AU - Weizman, Abraham
N1 - Funding Information:
This study was supported by the Vladimir Shreiber Medical Research Fund, Sackler Faculty of Medicine, Tel Aviv University. Israel (to Pavel Golubchik).
PY - 2009/1
Y1 - 2009/1
N2 - Accumulating data indicates that neurosteroids can modulate aggressive behavior. The aim of the present study was to examine neurosteroid blood levels in delinquent adolescent boys as compared to normal healthy controls. Dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S) and cortisol blood levels were measured in 16 delinquent adolescent (age 15.72 ± 0.95 years) with conduct disorder (CD) and 11 normal controls (16.82 ± 1.83 years). Severity of aggressive behavior was assessed by the Child Behavior Checklist (CBCL) and the Overt Aggression Scale (OAS). The delinquent adolescents tended to have higher DHEA-S levels than the normal control group (p = 0.054). DHEA and cortisol levels did not differ between the two groups. The interaction between neurosteroids ( especial DHEA-S) and genetic, developmental and environmental factors in juvenile delinquency merits further investigation.
AB - Accumulating data indicates that neurosteroids can modulate aggressive behavior. The aim of the present study was to examine neurosteroid blood levels in delinquent adolescent boys as compared to normal healthy controls. Dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S) and cortisol blood levels were measured in 16 delinquent adolescent (age 15.72 ± 0.95 years) with conduct disorder (CD) and 11 normal controls (16.82 ± 1.83 years). Severity of aggressive behavior was assessed by the Child Behavior Checklist (CBCL) and the Overt Aggression Scale (OAS). The delinquent adolescents tended to have higher DHEA-S levels than the normal control group (p = 0.054). DHEA and cortisol levels did not differ between the two groups. The interaction between neurosteroids ( especial DHEA-S) and genetic, developmental and environmental factors in juvenile delinquency merits further investigation.
KW - Aggression
KW - Cortisol
KW - Dehydroepiandrosterone (DHEA)
KW - Dehydroepiandrosterone sulfate (DHEA-S)
KW - Juvenile delinquency
KW - Neurosteroids
UR - http://www.scopus.com/inward/record.url?scp=57049181311&partnerID=8YFLogxK
U2 - 10.1016/j.euroneuro.2008.08.008
DO - 10.1016/j.euroneuro.2008.08.008
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C2 - 18835698
AN - SCOPUS:57049181311
VL - 19
SP - 49
EP - 52
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
SN - 0924-977X
IS - 1
ER -
