Neuropsychological characteristics as predictors of SSRI treatment response in depressed subjects

Marianne Gorlyn; John G. Keilp; Michael F. Grunebaum; Bonnie P. Taylor; Maria A. Oquendo; Gerard E. Bruder; Jonathan W. Stewart; Gil Zalsman; J. John Mann

doi:10.1007/s00702-008-0084-x

Neuropsychological characteristics as predictors of SSRI treatment response in depressed subjects

Marianne Gorlyn^*, John G. Keilp, Michael F. Grunebaum, Bonnie P. Taylor, Maria A. Oquendo, Gerard E. Bruder, Jonathan W. Stewart, Gil Zalsman, J. John Mann

^*Corresponding author for this work

Psychiatry

Research output: Contribution to journal › Article › peer-review

Abstract

Studies suggest that neuropsychological measures may provide prognostic information regarding SSRI treatment response, yet it is unclear which specific cognitive domains are the most effectual predictors. The aim of this study was to characterize the cognitive profile associated with SSRI nonresponse using a comprehensive set of neuropsychological tests. Participants (N = 32) met criteria for current major depressive episode. Assessment followed pre-treatment medication washout. Clinical response was measured after 3-month open-label SSRI treatment. Groups did not differ by demographic characteristics, intelligence or depression severity. Responders outperformed nonresponders across all cognitive domains, with the largest differences observed in executive, language and working memory functions. Results indicate poorer global cognitive functioning is predictive of treatment nonresponse. Deficits were most pronounced in tests demanding greater mental search and manipulation rather than speeded motor output. Cognitive slowing may mediate the working memory and executive function deficits found in nonresponders. These findings can inform exploration for pharmacogenetic endophenotypes.

Original language	English
Pages (from-to)	1213-1219
Number of pages	7
Journal	Journal of Neural Transmission
Volume	115
Issue number	8
DOIs	https://doi.org/10.1007/s00702-008-0084-x
State	Published - Aug 2008

Keywords

Depression
Neuropsychology
Response
SSRI

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00702-008-0084-x

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@article{f6d8c732726c4362ab3eacd630bd62cf,

title = "Neuropsychological characteristics as predictors of SSRI treatment response in depressed subjects",

abstract = "Studies suggest that neuropsychological measures may provide prognostic information regarding SSRI treatment response, yet it is unclear which specific cognitive domains are the most effectual predictors. The aim of this study was to characterize the cognitive profile associated with SSRI nonresponse using a comprehensive set of neuropsychological tests. Participants (N = 32) met criteria for current major depressive episode. Assessment followed pre-treatment medication washout. Clinical response was measured after 3-month open-label SSRI treatment. Groups did not differ by demographic characteristics, intelligence or depression severity. Responders outperformed nonresponders across all cognitive domains, with the largest differences observed in executive, language and working memory functions. Results indicate poorer global cognitive functioning is predictive of treatment nonresponse. Deficits were most pronounced in tests demanding greater mental search and manipulation rather than speeded motor output. Cognitive slowing may mediate the working memory and executive function deficits found in nonresponders. These findings can inform exploration for pharmacogenetic endophenotypes.",

keywords = "Depression, Neuropsychology, Response, SSRI",

author = "Marianne Gorlyn and Keilp, {John G.} and Grunebaum, {Michael F.} and Taylor, {Bonnie P.} and Oquendo, {Maria A.} and Bruder, {Gerard E.} and Stewart, {Jonathan W.} and Gil Zalsman and Mann, {J. John}",

note = "Funding Information: This research project was supported by National Institute of Mental Health grants MH-062155 and MH-062185, as well as awards from NARSAD and the American Foundation for Suicide Prevention to Dr. Keilp, and an award from the American Foundation for Suicide Prevention to Dr. Gorlyn. The authors thank Micky Gerchak for editing the manuscript.",

year = "2008",

month = aug,

doi = "10.1007/s00702-008-0084-x",

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volume = "115",

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AU - Gorlyn, Marianne

AU - Keilp, John G.

AU - Grunebaum, Michael F.

AU - Taylor, Bonnie P.

AU - Oquendo, Maria A.

AU - Bruder, Gerard E.

AU - Stewart, Jonathan W.

AU - Zalsman, Gil

AU - Mann, J. John

N1 - Funding Information: This research project was supported by National Institute of Mental Health grants MH-062155 and MH-062185, as well as awards from NARSAD and the American Foundation for Suicide Prevention to Dr. Keilp, and an award from the American Foundation for Suicide Prevention to Dr. Gorlyn. The authors thank Micky Gerchak for editing the manuscript.

PY - 2008/8

Y1 - 2008/8

N2 - Studies suggest that neuropsychological measures may provide prognostic information regarding SSRI treatment response, yet it is unclear which specific cognitive domains are the most effectual predictors. The aim of this study was to characterize the cognitive profile associated with SSRI nonresponse using a comprehensive set of neuropsychological tests. Participants (N = 32) met criteria for current major depressive episode. Assessment followed pre-treatment medication washout. Clinical response was measured after 3-month open-label SSRI treatment. Groups did not differ by demographic characteristics, intelligence or depression severity. Responders outperformed nonresponders across all cognitive domains, with the largest differences observed in executive, language and working memory functions. Results indicate poorer global cognitive functioning is predictive of treatment nonresponse. Deficits were most pronounced in tests demanding greater mental search and manipulation rather than speeded motor output. Cognitive slowing may mediate the working memory and executive function deficits found in nonresponders. These findings can inform exploration for pharmacogenetic endophenotypes.

AB - Studies suggest that neuropsychological measures may provide prognostic information regarding SSRI treatment response, yet it is unclear which specific cognitive domains are the most effectual predictors. The aim of this study was to characterize the cognitive profile associated with SSRI nonresponse using a comprehensive set of neuropsychological tests. Participants (N = 32) met criteria for current major depressive episode. Assessment followed pre-treatment medication washout. Clinical response was measured after 3-month open-label SSRI treatment. Groups did not differ by demographic characteristics, intelligence or depression severity. Responders outperformed nonresponders across all cognitive domains, with the largest differences observed in executive, language and working memory functions. Results indicate poorer global cognitive functioning is predictive of treatment nonresponse. Deficits were most pronounced in tests demanding greater mental search and manipulation rather than speeded motor output. Cognitive slowing may mediate the working memory and executive function deficits found in nonresponders. These findings can inform exploration for pharmacogenetic endophenotypes.

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Neuropsychological characteristics as predictors of SSRI treatment response in depressed subjects

Abstract

Keywords

UN SDGs

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