TY - JOUR
T1 - Neuropsychiatric manifestations in Langerhans cell histiocytosis disease
T2 - A case report and review of the literature
AU - Mimouni-Bloch, Aviva
AU - Schneider, Carolina
AU - Elishkevitz Politi, Keren
AU - Konen, Osnat
AU - Gothelf, Doron
AU - Stark, Batia
AU - Yaniv, Isaac
AU - Shuper, Avinoam
PY - 2010/7
Y1 - 2010/7
N2 - The spectrum of the possible manifestations of Langerhans cell histiocytosis in children is very wide, ranging from a simple rash to major multiorgan disease. There may be hypothalamic and pituitary dysfunction or more global neurological and neuropsychiatric manifestations when the central nervous system is affected. The cerebellum is preferentially affected for yet undetermined reasons. The clinical presentation includes motor dysfunction as well as cognitive, behavioral, and psychiatric expression of the ongoing neurodegeneration. We report a young patient with Langerhans cell histiocytosis who underwent an unusual course of psychiatric deterioration.
AB - The spectrum of the possible manifestations of Langerhans cell histiocytosis in children is very wide, ranging from a simple rash to major multiorgan disease. There may be hypothalamic and pituitary dysfunction or more global neurological and neuropsychiatric manifestations when the central nervous system is affected. The cerebellum is preferentially affected for yet undetermined reasons. The clinical presentation includes motor dysfunction as well as cognitive, behavioral, and psychiatric expression of the ongoing neurodegeneration. We report a young patient with Langerhans cell histiocytosis who underwent an unusual course of psychiatric deterioration.
KW - Langerhans cell histiocytosis
KW - cerebellar cognitive affective syndrome
KW - neuropsychiatric
UR - http://www.scopus.com/inward/record.url?scp=77954416832&partnerID=8YFLogxK
U2 - 10.1177/0883073809351317
DO - 10.1177/0883073809351317
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AN - SCOPUS:77954416832
SN - 0883-0738
VL - 25
SP - 884
EP - 887
JO - Journal of Child Neurology
JF - Journal of Child Neurology
IS - 7
ER -