Neuropsychiatric manifestations in Langerhans cell histiocytosis disease: A case report and review of the literature

Aviva Mimouni-Bloch, Carolina Schneider, Keren Elishkevitz Politi, Osnat Konen, Doron Gothelf, Batia Stark, Isaac Yaniv, Avinoam Shuper

Research output: Contribution to journalArticlepeer-review

Abstract

The spectrum of the possible manifestations of Langerhans cell histiocytosis in children is very wide, ranging from a simple rash to major multiorgan disease. There may be hypothalamic and pituitary dysfunction or more global neurological and neuropsychiatric manifestations when the central nervous system is affected. The cerebellum is preferentially affected for yet undetermined reasons. The clinical presentation includes motor dysfunction as well as cognitive, behavioral, and psychiatric expression of the ongoing neurodegeneration. We report a young patient with Langerhans cell histiocytosis who underwent an unusual course of psychiatric deterioration.

Original languageEnglish
Pages (from-to)884-887
Number of pages4
JournalJournal of Child Neurology
Volume25
Issue number7
DOIs
StatePublished - Jul 2010
Externally publishedYes

Keywords

  • Langerhans cell histiocytosis
  • cerebellar cognitive affective syndrome
  • neuropsychiatric

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