TY - JOUR
T1 - Neuroprotective therapy for argon-laser induced retinal injury
AU - Belkin, M.
AU - Rosner, M.
AU - Solberg, Y.
AU - Turetz, Y.
N1 - Funding Information:
We would like to thank Dr Galina Dubinsky for her invaluable technical assistance, and the photographer Tzvi Fridman for his help. We acknowlege Biotechnology General for the superoxide dismutase used in the research. The research was supported in part by BSF grant No 91-00225.
PY - 1999
Y1 - 1999
N2 - The efficacy of neuroprotective compounds in ameliorating laser-induced retinal damage was studied in a rat model. The laser injury mainly involved the outer layers of the retina, where it destroyed significant numbers of photoreceptor cells. Over time, evidence of two major histopathological processes was observed: traction of adjacent normal retinal cells into the central area of the lesion forming an internal retinal bulging; and a retinal pigmented epithelial proliferative reaction associated with subretinal neovascularization and invasion of the retinal lesion site by phagocytes. The neuroprotective compounds studied were corticosteroid methylprednisolone, glutamate-receptor blocker MK-801, antioxidant enzyme superoxide dismutase, and flunarizine.
AB - The efficacy of neuroprotective compounds in ameliorating laser-induced retinal damage was studied in a rat model. The laser injury mainly involved the outer layers of the retina, where it destroyed significant numbers of photoreceptor cells. Over time, evidence of two major histopathological processes was observed: traction of adjacent normal retinal cells into the central area of the lesion forming an internal retinal bulging; and a retinal pigmented epithelial proliferative reaction associated with subretinal neovascularization and invasion of the retinal lesion site by phagocytes. The neuroprotective compounds studied were corticosteroid methylprednisolone, glutamate-receptor blocker MK-801, antioxidant enzyme superoxide dismutase, and flunarizine.
UR - http://www.scopus.com/inward/record.url?scp=0032658103&partnerID=8YFLogxK
U2 - 10.1117/12.350604
DO - 10.1117/12.350604
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.conferencearticle???
AN - SCOPUS:0032658103
SN - 0277-786X
VL - 3591
SP - 407
EP - 421
JO - Proceedings of SPIE - The International Society for Optical Engineering
JF - Proceedings of SPIE - The International Society for Optical Engineering
T2 - Proceedings of the 1999 Ophthalmic Technologies IX
Y2 - 23 January 1999 through 25 January 1999
ER -