TY - JOUR
T1 - Neuroprotection in progressive brain disorders
AU - Djaldetti, Ruth
AU - Lev, Nirit
AU - Melamed, Eldad
PY - 2003/8/1
Y1 - 2003/8/1
N2 - Progressive neurodegenerative disorders share common mechanisms of cell death, and in all likelihood multiple factors are involved in every disease. Therefore, several neuroprotective agents are being investigated with the purpose of slowing or preventing further deterioration of cell toss. These include experimental animal and clinical studies on the neuroprotective effects of caspase inhibitors, antioxidants, glutamate antagonists, anti-inflammatory agents and trophic factors in several neurodegenerative diseases. At present there is limited clinical evidence for direct neuroprotective effects against these diseases, but much effort is being invested in research on novel technologies and compounds.
AB - Progressive neurodegenerative disorders share common mechanisms of cell death, and in all likelihood multiple factors are involved in every disease. Therefore, several neuroprotective agents are being investigated with the purpose of slowing or preventing further deterioration of cell toss. These include experimental animal and clinical studies on the neuroprotective effects of caspase inhibitors, antioxidants, glutamate antagonists, anti-inflammatory agents and trophic factors in several neurodegenerative diseases. At present there is limited clinical evidence for direct neuroprotective effects against these diseases, but much effort is being invested in research on novel technologies and compounds.
KW - Degenerative diseases
KW - Neuroprotection
UR - http://www.scopus.com/inward/record.url?scp=0043067060&partnerID=8YFLogxK
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AN - SCOPUS:0043067060
SN - 1565-1088
VL - 5
SP - 576
EP - 580
JO - Israel Medical Association Journal
JF - Israel Medical Association Journal
IS - 8
ER -
