Neuronal fiber delineation in area of edema from diffusion weighted MRI

Ofer Pasternak*, Nir Sochen, Nathan Intrator, Yaniv Assaf

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Diffusion Tensor Magnetic Resonance Imaging (DT-MRI) is a non invasive method for brain neuronal fibers delineation. Here we show a modification for DT-MRI that allows delineation of neuronal fibers which are infiltrated by edema. We use the Muliple Tensor Variational (MTV) framework which replaces the diffusion model of DT-MRI with a multiple component model and fits it to the signal attenuation with a variational regularization mechanism. In order to reduce free water contamination we estimate the free water compartment volume fraction in each voxel, remove it, and then calculate the anisotropy of the remaining compartment. The variational framework was applied on data collected with conventional clinical parameters, containing only six diffusion directions. By using the variational framework we were able to overcome the highly ill posed fitting. The results show that we were able to find fibers that were not found by DT-MRI.

Original languageEnglish
Title of host publicationAdvances in Neural Information Processing Systems 18 - Proceedings of the 2005 Conference
Pages1075-1080
Number of pages6
StatePublished - 2005
Event2005 Annual Conference on Neural Information Processing Systems, NIPS 2005 - Vancouver, BC, Canada
Duration: 5 Dec 20058 Dec 2005

Publication series

NameAdvances in Neural Information Processing Systems
ISSN (Print)1049-5258

Conference

Conference2005 Annual Conference on Neural Information Processing Systems, NIPS 2005
Country/TerritoryCanada
CityVancouver, BC
Period5/12/058/12/05

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