Neuronal fate determinants of adult olfactory bulb neurogenesis

Michael A. Hack, Armen Saghatelyan, Antoine De Chevigny, Alexander Pfeifer, Ruth Ashery-Padan, Pierre Marie Lledo*, Magdalena Götz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

523 Scopus citations

Abstract

Adult neurogenesis in mammals is restricted to two small regions, including the olfactory bulb, where GABAergic and dopaminergic interneurons are newly generated throughout the entire lifespan. However, the mechanisms directing them towards a specific neuronal phenotype are not yet understood. Here, we demonstrate the dual role of the transcription factor Pax6 in generating neuronal progenitors and also in directing them towards a dopaminergic periglomerular phenotype in adult mice. We present further evidence that dopaminergic periglomerular neurons originate in a distinct niche, the rostral migratory stream, and are fewer derived from precursors in the zone lining the ventricle. This regionalization of the adult precursor cells is further supported by the restricted expression of the transcription factor Olig2, which specifies transit-amplifying precursor fate and opposes the neurogenic role of Pax6. Together, these data explain both extrinsic and intrinsic mechanisms controlling neuronal identity in adult neurogenesis.

Original languageEnglish
Pages (from-to)865-872
Number of pages8
JournalNature Neuroscience
Volume8
Issue number7
DOIs
StatePublished - 25 Jul 2005

Funding

FundersFunder number
Association Française contre les Myopathies
Deutsche Forschungsgemeinschaft
German-Israeli Foundation for Scientific Research and Development
Israel Science Foundation401/02
Centre National de la Recherche Scientifique
Institute Pasteur De Lille

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