TY - JOUR
T1 - Neurological outcome in isolated congenital heart block and hydrops fetalis
AU - Breur, Johannes M.P.J.
AU - Gooskens, Rob H.J.M.
AU - Kapusta, Livia
AU - Stoutenbeek, Philip
AU - Visser, Gerard H.A.
AU - Van Den Berg, Paul
AU - Meijboom, Erik J.
PY - 2007/10
Y1 - 2007/10
N2 - Objective: Isolated fetal heart block (HB), a condition associated with fetal hydrops, carries a high mortality rate and may result in neurodevelopmental sequelae. To the best of our knowledge, no data exist regarding the long-term outcome of such hydropic fetuses. We reviewed our experience with this condition to determine the neurodevelopmental outcome of prenatally diagnosed cases with isolated HB complicated by hydrops fetalis. Methods: Neurodevelopmental assessment of 5 children presented prenatally with isolated HB associated with hydrops fetalis. Results: During the last 18 years, 10 cases were detected prenatally with isolated HB and hydrops fetalis. 3 of the 10 fetuses died in utero, and 2 died postnatally, due to a dilated cardiomyopathy, at the age of 9 months and 4 years, respectively. Neurodevelopmental studies done on the 5 remaining children were normal. Conclusion: Long-term neurodevelopmental assessments of 5 surviving cases presented prenatally with isolated HB and hydrops fetalis are reassuring.
AB - Objective: Isolated fetal heart block (HB), a condition associated with fetal hydrops, carries a high mortality rate and may result in neurodevelopmental sequelae. To the best of our knowledge, no data exist regarding the long-term outcome of such hydropic fetuses. We reviewed our experience with this condition to determine the neurodevelopmental outcome of prenatally diagnosed cases with isolated HB complicated by hydrops fetalis. Methods: Neurodevelopmental assessment of 5 children presented prenatally with isolated HB associated with hydrops fetalis. Results: During the last 18 years, 10 cases were detected prenatally with isolated HB and hydrops fetalis. 3 of the 10 fetuses died in utero, and 2 died postnatally, due to a dilated cardiomyopathy, at the age of 9 months and 4 years, respectively. Neurodevelopmental studies done on the 5 remaining children were normal. Conclusion: Long-term neurodevelopmental assessments of 5 surviving cases presented prenatally with isolated HB and hydrops fetalis are reassuring.
KW - Atrioventricular block
KW - Congenital heart block
KW - Fetal hydrops
KW - Heart block
KW - Neurological outcome, congenital heart block/fetal hydrops
KW - Pediatric cardiology
UR - http://www.scopus.com/inward/record.url?scp=35548958763&partnerID=8YFLogxK
U2 - 10.1159/000106355
DO - 10.1159/000106355
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C2 - 17652937
AN - SCOPUS:35548958763
VL - 22
SP - 457
EP - 461
JO - Fetal Diagnosis and Therapy
JF - Fetal Diagnosis and Therapy
SN - 1015-3837
IS - 6
ER -