Neurological complications in Down's Syndrome

Nirit Lev, Eldad Melamed

Research output: Contribution to journalReview articlepeer-review


Down's syndrome (trisomy 21) is the most common chromosomal aberration and is one of the major reasons for mental retardation. Down's syndrome has manifestations in many systems. The syndrome has many neurological complications, which include structural changes, mental retardation, young-onset Alzheimer's disease, strokes and basal ganglia damage. Epileptic seizures are more prevalent in Down's syndrome patients than in the general population. Cervical spinal cord instability, which is common in Down's syndrome, can cause neurological complications resulting from cervical spinal cord compression. The aim of this article is to review the neurological complications of Down's syndrome in order to increase awareness and assist doctors in diagnosis and counseling the patients' families.

Original languageEnglish
Pages (from-to)820-823, 857
Issue number9
StatePublished - Sep 2002
Externally publishedYes


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