Neurologic complications of orthotopic liver transplantation.

D. J. Bronster*, S. Emre, E. Mor, P. Sheiner, C. M. Miller, M. E. Schwartz

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations


Neurologic complications are frequent after liver transplantation and are the cause of significant morbidity and mortality. A substantial proportion of the neurologic complications encountered after transplant is iatrogenic--the consequence of the harsh therapeutic interventions required to maintain function of the transplanted liver. The preoperative condition of the patient is also a major determinant of the incidence and impact of neurologic complications, as is the occurrence of poor early graft function or of repeated rejection episodes that require augmented immunosuppression. By recognizing the early signs of drug-related neurotoxicity, it is often possible to preempt the development of more severe trouble. Careful perioperative fluid management, specifically related to sodium and glucose levels, may reduce the risk of CPM. As effective treatment modalities have emerged, an aggressive approach to the diagnosis of central nervous system infection has assumed increased importance. With persistent attention to the details of basic patient care as well as to the specific neurologic diagnosis, and with a commitment to intensive rehabilitation therapy, the large majority of patients who suffer neurologic complications after transplant can ultimately return to a productive life.

Original languageEnglish
Pages (from-to)63-69
Number of pages7
JournalAnnals of Global Health
Issue number1
StatePublished - Jan 1994
Externally publishedYes


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