Neuroleptics reduce spinal fluid cyclic AMP in schizophrenic patients

J. Biederman, R. Rimon, R. Ebstein, J. Zohar, R. Belmaker

Research output: Contribution to journalArticlepeer-review


Cyclic AMP in the cerebrospinal fluid (CSF) was determined in a group of 10 schizophrenic patients before neuroleptic drug treatment and after a mean of 8 wk antipsychotic drug therapy. For 8 patients with marked to moderate treatment response a significant decline in CSF cyclic AMP was observed. This result is consistent with the theory that blockade of postsynaptic dopamine receptors is a major mechanism of the antipsychotic action of neuroleptic drugs.

Original languageEnglish
Pages (from-to)324-327
Number of pages4
JournalUnknown Journal
Issue number5-6
StatePublished - 1977


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