Neuroendocrine mechanisms in fibromyalgia-chronic fatigue

Dan Buskila*, Joseph Press

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Fibromyalgia and chronic fatigue syndrome are poorly understood disorders that share similar demographic and clinical characteristics. Because of the clinical similarities between both disorders it was suggested that they share a common pathophysiology mechanism, namely, central nervous system dysfunction. This chapter presents data demonstrating neurohormonal abnormalities, abnormal pain processing and autonomic nervous system dysfunction in fibromyalgia and chronic fatigue syndrome. The possible contribution of the central nervous system dysfunction to the development and symptomatology of these conditions is discussed. The chapter concludes by reviewing the effect of current treatments and emerging therapeutic modalities in fibromyalgia and chronic fatigue syndrome.

Original languageEnglish
Pages (from-to)747-758
Number of pages12
JournalBest Practice and Research in Clinical Rheumatology
Issue number5
StatePublished - 2001
Externally publishedYes


  • Central sensitization
  • Chronic fatigue syndrome
  • Dysautonomia
  • Fibromyalgia
  • Neuroendocrine dysregulation
  • Treatment


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