Neurodevelopmental outcome of fetal isolated ventricular asymmetry without dilation: a cohort study

R. Meyer, O. Bar-Yosef, E. Barzilay, D. Hoffman, S. Toussia-Cohen, E. Zvi, R. Achiron, E. Katorza

Research output: Contribution to journalArticlepeer-review


Objective: Fetal isolated ventricular asymmetry (IVA) is a relatively common finding in pregnancy, but data regarding its effect on neurodevelopmental outcome are scarce and founded principally on ultrasound-based studies. The purpose of this study was to assess the neurodevelopmental outcome of IVA cases in a magnetic resonance imaging (MRI)-based study. Methods: Cases referred for fetal brain MRI as part of the assessment of IVA without ventriculomegaly (lateral ventricular atrial diameter ≤ 10 mm), identified during routine ultrasound examination, were assessed for possible inclusion. Asymmetry was defined as a difference in width of ≥ 2 mm between the two lateral ventricles. Forty-three cases were included in the study group and compared with a control group of 94 normal cases without IVA. Children were assessed at ages 13–74 months using the Vineland-II Adaptive Behavior Scales (VABS-II). Results: VABS-II scores were within normal range. There was no significant difference in composite VABS-II score between the study and control groups (106.5 vs 108.0; P = 0.454). VABS-II scores did not differ between the groups when matched for gender and age at VABS-II interview (109.6 in study group vs 107.8 in control group; P = 0.690). Conclusion: In cases of IVA without ventriculomegaly on MRI, neurodevelopmental test scores were normal and did not differ from cases without IVA.

Original languageEnglish
JournalUltrasound in Obstetrics and Gynecology
StatePublished - 1 Jan 2018


  • MRI
  • fetal brain
  • neurodevelopmental outcome
  • ultrasound
  • ventricular asymmetry


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