Neurobehavioral development of neonatal mice following blockade of VIP during the early embryonic period

Joyce Y. Wu, Karin A. Henins, Pierre Gressens, Illana Gozes, Mati Fridkin, Douglas E. Brenneman, Joanna M. Hill*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Previous work has shown that blockade of VIP function in the early postimplantation embryo results in growth retardation and microcephaly. In the present work, the neurobehavioral development of neonatal mice was examined following treatment of dams with a VIP antagonist during this period. Inhibition of VIP functions during early embryogenesis impaired the performance of 5 of 10 developmental behaviors. These behaviors included developmental milestones (first appearance of ear twitch and eye opening) and complex motor behaviors (negative geotaxis, surface righting, and air righting). The retardation of neurobehavioral development produced by inhibition of VIP action indicates that this peptide is important to the progression of embryonic development.

Original languageEnglish
Pages (from-to)1131-1137
Number of pages7
JournalPeptides
Volume18
Issue number8
DOIs
StatePublished - 1997

Keywords

  • Developmental milestones
  • Developmental retardation
  • Mouse embryos
  • Neurobehavioral development
  • VIP antagonist
  • Vasoactive intestinal peptide

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