TY - JOUR
T1 - Neural modulation of immunity
T2 - Conditioning phenomena and the adaptability of lymphoid cells
AU - Grossman, Zvi
AU - Herberman, Ronald B.
AU - Livnat, Shmuel
PY - 1992
Y1 - 1992
N2 - The behavioral conditioning of alterations in the immune response is one pillar supporting the growing edifice of central nervous system (CNS) modulation of immunity. The mechanisms underlying such conditioning phenomena are not understood. In this communication, we attempt to develop a theoretical position based on the concept of phenotypic and functional adaptability of lymphoid cells. We propose that these cells can learn to associate responsiveness to antigens and to other immunoactive" agents, with responsiveness to signals originating in the CNS delivered via neuroendocrine or autonomic nervous channels. Neural/endocrine signals act on the immune system in conjunction with immunological stimuli, in a way that leads to storage" of the association (memory) of these two kinds of stimuli in the immune system rather than in the brain.
AB - The behavioral conditioning of alterations in the immune response is one pillar supporting the growing edifice of central nervous system (CNS) modulation of immunity. The mechanisms underlying such conditioning phenomena are not understood. In this communication, we attempt to develop a theoretical position based on the concept of phenotypic and functional adaptability of lymphoid cells. We propose that these cells can learn to associate responsiveness to antigens and to other immunoactive" agents, with responsiveness to signals originating in the CNS delivered via neuroendocrine or autonomic nervous channels. Neural/endocrine signals act on the immune system in conjunction with immunological stimuli, in a way that leads to storage" of the association (memory) of these two kinds of stimuli in the immune system rather than in the brain.
KW - Adaptive differentiation
KW - Associative learning
KW - CNS
KW - Conditioning
KW - Immunity
KW - Neural modulation
KW - Pattern recognition
UR - http://www.scopus.com/inward/record.url?scp=0026854883&partnerID=8YFLogxK
U2 - 10.3109/00207459209000555
DO - 10.3109/00207459209000555
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AN - SCOPUS:0026854883
SN - 0020-7454
VL - 64
SP - 275
EP - 290
JO - International Journal of Neuroscience
JF - International Journal of Neuroscience
IS - 1-4
ER -