Neural modelling of cognitive disinhibition and neurotransmitter dysfunction in OCD

Jacques Ludik; Dan J. Stein

doi:10.1007/3-540-61510-5_150

Neural modelling of cognitive disinhibition and neurotransmitter dysfunction in OCD

Jacques Ludik, Dan J. Stein

Stellenbosch University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

In this paper an Elman recurrent neural network model of obsessive-compulsive disorder (OCD) is developed to provide a simulation of the relationship between the cognitive disinhibition and serotonin/dopamine dysfunction that characterize this disorder. Cognitive disinhibition in OCD is apparent when OCD patients are compared with other anxiety disorder patients on a Temporal Stroop test, with OCD patients showing reduced negative priming. Alterations of the color gain parameter, the context gain parameter, and maximum cycle number were made in order to simulate changes in monoamine neutransmitter function. The recurrent network model was able to simulate reduced cognitive inhibition as well as serotonergic and dopaminergic dysfunction in OCD.

Original language	English
Title of host publication	Artificial Neural Networks, ICANN 1996 - 1996 International Conference, Proceedings
Publisher	Springer Verlag
Pages	893-898
Number of pages	6
ISBN (Print)	3540615105, 9783540615101
DOIs	https://doi.org/10.1007/3-540-61510-5_150
State	Published - 1996
Externally published	Yes
Event	1996 International Conference on Artificial Neural Networks, ICANN 1996 - Bochum, Germany Duration: 16 Jul 1996 → 19 Jul 1996

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume	1112 LNCS
ISSN (Print)	0302-9743
ISSN (Electronic)	1611-3349

Conference

Conference	1996 International Conference on Artificial Neural Networks, ICANN 1996
Country/Territory	Germany
City	Bochum
Period	16/07/96 → 19/07/96

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10.1007/3-540-61510-5_150

Cite this

Ludik, J., & Stein, D. J. (1996). Neural modelling of cognitive disinhibition and neurotransmitter dysfunction in OCD. In Artificial Neural Networks, ICANN 1996 - 1996 International Conference, Proceedings (pp. 893-898). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 1112 LNCS). Springer Verlag. https://doi.org/10.1007/3-540-61510-5_150

Ludik, Jacques ; Stein, Dan J. / Neural modelling of cognitive disinhibition and neurotransmitter dysfunction in OCD. Artificial Neural Networks, ICANN 1996 - 1996 International Conference, Proceedings. Springer Verlag, 1996. pp. 893-898 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).

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Ludik, J & Stein, DJ 1996, Neural modelling of cognitive disinhibition and neurotransmitter dysfunction in OCD. in Artificial Neural Networks, ICANN 1996 - 1996 International Conference, Proceedings. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 1112 LNCS, Springer Verlag, pp. 893-898, 1996 International Conference on Artificial Neural Networks, ICANN 1996, Bochum, Germany, 16/07/96. https://doi.org/10.1007/3-540-61510-5_150

Neural modelling of cognitive disinhibition and neurotransmitter dysfunction in OCD. / Ludik, Jacques; Stein, Dan J.
Artificial Neural Networks, ICANN 1996 - 1996 International Conference, Proceedings. Springer Verlag, 1996. p. 893-898 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 1112 LNCS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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Ludik J, Stein DJ. Neural modelling of cognitive disinhibition and neurotransmitter dysfunction in OCD. In Artificial Neural Networks, ICANN 1996 - 1996 International Conference, Proceedings. Springer Verlag. 1996. p. 893-898. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). doi: 10.1007/3-540-61510-5_150

Neural modelling of cognitive disinhibition and neurotransmitter dysfunction in OCD

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